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环保型聚乙二醇（PEG - 400）：一种用于在室温下一步法四组分合成新型不对称双螺吲哚酮衍生物的绿色反应介质。

Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature.

作者信息

Hasaninejad Alireza, Beyrati Maryam

机构信息

Department of Chemistry, Faculty of Sciences, Persian Gulf University Bushehr 7516913817 Iran

出版信息

RSC Adv. 2018 Jan 9;8(4):1934-1939. doi: 10.1039/c7ra13133j. eCollection 2018 Jan 5.

DOI:10.1039/c7ra13133j
PMID:35542580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077237/
Abstract

PEG-400 has been used as a green and biodegradable polymeric solvent for the one-pot, two-step, multi-component synthesis of novel asymmetrical bis-spirooxindole derivatives by the reaction of -alkyl isatin, isatin derivatives, alkylmalonates and C-H activated carbonyl compounds in the presence of KCO at room temperature. Using this procedure, all the products were obtained in good to excellent yields.

摘要

聚乙二醇400（PEG - 400）已被用作一种绿色且可生物降解的聚合溶剂，用于在室温下，在碳酸钾存在的条件下，通过α-烷基异吲哚酮、异吲哚酮衍生物、丙二酸酯与C-H活化羰基化合物的反应，一锅法两步多组分合成新型不对称双螺环氧化吲哚衍生物。采用此方法，所有产物的产率均良好至优异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/b0dd4c9c43e5/c7ra13133j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/f3c193e98a85/c7ra13133j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/c29a00079a0c/c7ra13133j-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/b0dd4c9c43e5/c7ra13133j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/f3c193e98a85/c7ra13133j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/c29a00079a0c/c7ra13133j-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5c/9077237/b0dd4c9c43e5/c7ra13133j-f1.jpg

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2
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Bioorg Med Chem. 2016 Mar 15;24(6):1408-17. doi: 10.1016/j.bmc.2016.02.019. Epub 2016 Feb 10.
3
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Mol Divers. 2022 Dec;26(6):3411-3445. doi: 10.1007/s11030-021-10376-3. Epub 2022 Jan 15.
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