Department of Chemistry, Mahatma Gandhi Vidyamandir's Loknete Vyankatrao Hiray Arts, Science and Commerce College, Panchavati (Affiliated to Savitribai Phule Pune University, Pune), Nashik, 422003, India.
Mol Divers. 2023 Dec;27(6):2441-2452. doi: 10.1007/s11030-022-10562-x. Epub 2022 Nov 11.
A new series of 1,3,5-trisubstituted 2-pyrazoline derivatives (3a-l) are synthesized in good to excellent yields from the corresponding chalcones (1a-h) and acid hydrazides (2a-e) in polyethylene glycol-400 (PEG-400) as a green reaction medium. The newly synthesized 2-pyrazoline derivatives are screened for their antibacterial and antifungal activity. The synthesized trisubstituted pyrazolines displayed moderate to good antibacterial and antifungal properties as compared with the standard reference penicillin and fluconazole drugs. Additionally, the antioxidant potential of the 1,3,5-trisubstituted 2-pyrazolines is evaluated by OH and DPPH assay. The 1,3,5-trisubstituted 2-pyrazolines showed good radical scavenger activity and were found as good antioxidant agents.
从相应的查尔酮（1a-h）和酸酰肼（2a-e）出发，在聚乙二醇-400（PEG-400）中以绿色反应介质，合成了一系列新的 1,3,5-三取代 2-吡唑啉衍生物（3a-l），产率良好到优秀。新合成的 2-吡唑啉衍生物经过了抗菌和抗真菌活性的筛选。与标准参考青霉素和氟康唑药物相比，所合成的三取代吡唑啉显示出中等至良好的抗菌和抗真菌特性。此外，通过 OH 和 DPPH 测定评估了 1,3,5-三取代 2-吡唑啉的抗氧化潜力。1,3,5-三取代 2-吡唑啉显示出良好的自由基清除活性，被发现是良好的抗氧化剂。
