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室温下一步法顺序四组分合成新型杂环[3.3.3] 螺旋烷衍生物

One-pot, sequential four-component synthesis of novel heterocyclic [3.3.3] propellane derivatives at room temperature.

作者信息

Beyrati Maryam, Hasaninejad Alireza

机构信息

Department of Chemistry, Faculty of Sciences, Persian Gulf University Bushehr 7516913817 Iran

出版信息

RSC Adv. 2018 Apr 17;8(26):14171-14176. doi: 10.1039/c8ra01648h.

DOI:10.1039/c8ra01648h
PMID:35540742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9079859/
Abstract

An efficient, one-pot, two-step, four-component reaction for the synthesis of propellane derivatives is described by the condensation reaction between acenaphthenequinone, malono derivatives, primary amines and β-ketoester or β-diketone derivatives in the presence of triethylamine in ethanol at room temperature. Using this procedure, all the products were obtained in good to excellent yields.

摘要

描述了一种用于合成螺桨烷衍生物的高效、一锅两步四组分反应，该反应是在室温下，苊醌、丙二酸衍生物、伯胺与β-酮酯或β-二酮衍生物在乙醇中三乙胺存在下通过缩合反应进行的。采用此方法，所有产物的产率均良好至优异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/c07aedeceaa2/c8ra01648h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/cad0ca94dc00/c8ra01648h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/2e80da8b73b8/c8ra01648h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/c504e39ede55/c8ra01648h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/c07aedeceaa2/c8ra01648h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/cad0ca94dc00/c8ra01648h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/2e80da8b73b8/c8ra01648h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/c504e39ede55/c8ra01648h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/9079859/c07aedeceaa2/c8ra01648h-s2.jpg

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