Tim Banh, University of California San Francisco, USA,
J Prev Alzheimers Dis. 2022;9(2):262-268. doi: 10.14283/jpad.2021.68.
The feasibility and validity of unsupervised, longitudinal brief computerized cognitive batteries is unknown.
Participants aged 56-90 (N = 19476) from the Brain Health Registry (BHR) completed the CogState Brief Battery (CBB) at 6-month intervals over a period of 5 years. We used linear mixed-effects models to assess whether cross-sectional and longitudinal performance on CBB within BHR was associated with demographic and cognitive characteristics. We also defined a group of CBB decliners based on subject-specific slopes and estimated associations between decliner status and participant characteristics.
We found weak associations between longitudinal change in CBB and participant characteristics. Cross-sectional CBB scores were significantly associated with participant characteristics such as age, gender, ethnicity, self-reported disease status, and memory concern. CBB decliners were more likely to self-report mild cognitive impairment (MCI) and memory concerns.
Cross-sectional, remote CBB shows evidence of construct validity, but our results suggest that longitudinal assessment may not provide additional value for identifying those at risk for and with cognitive impairment.
未经监督的、纵向的简短计算机认知电池的可行性和有效性尚不清楚。
来自大脑健康登记处（BHR）的年龄在 56-90 岁的参与者（N=19476）在 5 年内每 6 个月完成一次 CogState 简短电池测试（CBB）。我们使用线性混合效应模型来评估 BHR 内 CBB 的横断面和纵向表现是否与人口统计学和认知特征相关。我们还根据受试者特定的斜率定义了一组 CBB 下降者，并估计了下降者状态与参与者特征之间的关联。
我们发现 CBB 的纵向变化与参与者特征之间存在弱关联。CBB 的横断面分数与参与者特征如年龄、性别、种族、自我报告的疾病状况和记忆关注显著相关。CBB 下降者更有可能自我报告轻度认知障碍（MCI）和记忆问题。
横断面、远程 CBB 显示出结构有效性的证据，但我们的结果表明，纵向评估可能无法为识别那些有认知障碍风险和患有认知障碍的人提供额外的价值。
