Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
J Asian Nat Prod Res. 2023 Feb;25(2):139-146. doi: 10.1080/10286020.2022.2072734. Epub 2022 May 11.
Two new tricyclic pyridone analogues, fusapyridons C () and D (), were isolated along with structurally related known compounds - from the entomopathogenic fungus, SYKC02-P-1. The structures of compounds and were elucidated by analyzing the spectral data of UV, 1 D and 2 D NMR as well as HRESIMS. The absolute configurations of fusapyridons C and D were established by means of single crystal X-ray diffraction and electronic circular dichroism calculation. And antitumor testing of all the isolates showed that compounds and exhibited significant inhibitory activity against the human prostate cancer cells (PC-3 cell lines) with IC values of 2.76 and 1.86 μM, respectively.
两种新的三环吡啶酮类似物，fusapyridons C()和 D()，与结构相关的已知化合物一起从昆虫病原真菌 SYKC02-P-1 中分离出来。通过分析 UV、1D 和 2D NMR 以及 HRESIMS 的光谱数据，阐明了化合物和的结构。通过单晶 X 射线衍射和电子圆二色性计算确定了 fusapyridons C 和 D 的绝对构型。所有分离物的抗肿瘤测试表明，化合物和对人前列腺癌细胞（PC-3 细胞系）表现出显著的抑制活性，IC 值分别为 2.76 和 1.86 μM。
