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线粒体抗病毒信号蛋白是 BAG6 蛋白质量控制复合物的客户。

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.

机构信息

Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.

出版信息

J Cell Sci. 2022 May 1;135(9). doi: 10.1242/jcs.259596. Epub 2022 May 11.

DOI:10.1242/jcs.259596
PMID:35543156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9264363/
Abstract

The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable complex with this cytosolic protein quality control factor, enabling such clients to be either productively re-routed or selectively degraded. We identify the mitochondrial antiviral-signalling protein (MAVS) as an endogenous TA client of both SGTA and the BAG6 complex. Our data suggest that the BAG6 complex binds to a cytosolic pool of MAVS before its misinsertion into the ER membrane, from where it can subsequently be removed via ATP13A1-mediated dislocation. This BAG6-associated fraction of MAVS is dynamic and responds to the activation of an innate immune response, suggesting that BAG6 may modulate the pool of MAVS that is available for coordinating the cellular response to viral infection.

摘要

三聚体 BAG6 复合物协调新合成的尾部锚定 (TA) 膜蛋白从 SGTA 结合的预加载复合物直接递送至内质网 (ER) 递送成分 TRC40。相比之下，有缺陷的前体，包括异常的 TA 蛋白，与这种细胞质蛋白质量控制因子形成稳定的复合物，使这些客户能够有效地重新定向或选择性降解。我们确定线粒体抗病毒信号蛋白 (MAVS) 是 SGTA 和 BAG6 复合物的内源性 TA 客户。我们的数据表明，BAG6 复合物在其错误插入内质网膜之前与 MAVS 的细胞质池结合，随后可以通过 ATP13A1 介导的易位将其去除。MAVS 的这种 BAG6 相关部分是动态的，并响应先天免疫反应的激活，表明 BAG6 可能调节可用于协调细胞对病毒感染反应的 MAVS 池。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/bec972fb03be/joces-135-259596-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/03a8701aff09/joces-135-259596-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/4034ba1194d0/joces-135-259596-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/37b0dba6b57f/joces-135-259596-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/5564e6470174/joces-135-259596-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/579e10b0a530/joces-135-259596-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/bd374b8b4584/joces-135-259596-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/bec972fb03be/joces-135-259596-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/03a8701aff09/joces-135-259596-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/4034ba1194d0/joces-135-259596-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/37b0dba6b57f/joces-135-259596-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/5564e6470174/joces-135-259596-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/579e10b0a530/joces-135-259596-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/bd374b8b4584/joces-135-259596-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f6/9264363/bec972fb03be/joces-135-259596-g7.jpg

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5
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Commun Biol. 2021 Jul 1;4(1):828. doi: 10.1038/s42003-021-02363-z.
6
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FEBS J. 2022 Nov;289(22):6835-6862. doi: 10.1111/febs.15905. Epub 2021 Jun 5.
7
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J Biol Chem. 2021 Jan-Jun;296:100441. doi: 10.1016/j.jbc.2021.100441. Epub 2021 Feb 19.
8
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