Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Nutr Cancer. 2022;74(9):3302-3311. doi: 10.1080/01635581.2022.2074472. Epub 2022 May 11.
Computed tomography (CT)-assessed body composition is considered a novel prognostic factor for cancer patients. Owing to the need for new prognostic markers for hepatocellular carcinoma (HCC) patients undergoing radiotherapy, we investigated the impact of body composition on outcomes in this patient population. We retrospectively evaluated 109 HCC patients receiving radiotherapy. The skeletal muscle index, subcutaneous adipose tissue index (SATI), and visceral adipose tissue index within 1 mo, before radiotherapy were assessed based on a single CT image slice at the level of the third lumbar (L3) vertebra. The impact of body composition parameters on progression-free survival (PFS) and overall survival (OS) was assessed. Overall, 62 (56.9%) patients died, and 47 (43.1%) patients experienced recurrence during a median follow-up period of 20.5 mo. Multivariate analysis revealed that SATI was an independent prognostic factor for both PFS (hazard ratio [HR] 0.542, = 0.025) and OS (HR 0.385, = 0.005). Patients with high SATI ( = 43) had significantly better PFS ( = 0.0093) and OS ( = 0.032) than those with low SATI ( = 66). CT-assessed SATI is an independent prognostic factor in HCC patients receiving radiotherapy. Further validation is warranted to determine whether this finding can be translated into other study populations.
计算机断层扫描（CT）评估的身体成分被认为是癌症患者的一种新的预后因素。由于需要新的预后标志物来评估接受放疗的肝细胞癌（HCC）患者，我们研究了身体成分对该患者人群结局的影响。我们回顾性评估了 109 例接受放疗的 HCC 患者。根据第三腰椎（L3）水平单次 CT 图像切片评估了骨骼肌指数、皮下脂肪组织指数（SATI）和内脏脂肪组织指数，这些指数是在放疗前 1 个月内评估的。评估了身体成分参数对无进展生存期（PFS）和总生存期（OS）的影响。总体而言，62 例（56.9%）患者死亡，47 例（43.1%）患者在中位随访 20.5 个月期间复发。多变量分析显示，SATI 是 PFS（风险比[HR]0.542，=0.025）和 OS（HR 0.385，=0.005）的独立预后因素。SATI 较高（=43）的患者的 PFS（=0.0093）和 OS（=0.032）明显优于 SATI 较低（=66）的患者。CT 评估的 SATI 是接受放疗的 HCC 患者的独立预后因素。需要进一步验证，以确定这一发现是否可以转化为其他研究人群。
