• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

具有混合 ROS 的水溶性亮近红外 AIEgens,用于免洗线粒体“开-关”成像和光动力治疗。

Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial "off-on" imaging and photodynamic therapy.

机构信息

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.

NingboTech University, Ningbo, 315100, Zhejiang, P. R. China.

出版信息

Chem Commun (Camb). 2022 May 30;58(44):6393-6396. doi: 10.1039/d2cc01559e.

DOI:10.1039/d2cc01559e
PMID:35543244
Abstract

Several aggregation-induced emission luminogens (AIEgens) with excellent water-solubility and near-infrared emission were designed and synthesized for wash-free "off-on" mitochondrial imaging and photodynamic therapy of HeLa cells. The AIEgen TEPP exhibits both bright near-infrared emission ( = 17.8%) and high hybrid ROS productivity (including OH˙ and O).

摘要

几种具有良好水溶性和近红外发射的聚集诱导发光材料(AIEgens)被设计和合成,用于 HeLa 细胞无冲洗的线粒体成像和光动力治疗。AIEgen TEPP 表现出明亮的近红外发射( = 17.8%)和高混合 ROS 生成能力(包括 OH˙和 O)。

相似文献

1
Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial "off-on" imaging and photodynamic therapy.具有混合 ROS 的水溶性亮近红外 AIEgens,用于免洗线粒体“开-关”成像和光动力治疗。
Chem Commun (Camb). 2022 May 30;58(44):6393-6396. doi: 10.1039/d2cc01559e.
2
Multifunctional Two-Photon AIE Luminogens for Highly Mitochondria-Specific Bioimaging and Efficient Photodynamic Therapy.多功能双光子聚集诱导发光材料用于高度线粒体特异性生物成像和高效光动力治疗。
ACS Appl Mater Interfaces. 2019 Jun 12;11(23):20715-20724. doi: 10.1021/acsami.9b04813. Epub 2019 May 30.
3
Mitochondria-targeted pentacyclic triterpene NIR-AIE derivatives for enhanced chemotherapeutic and chemo-photodynamic combined therapy.线粒体靶向五环三萜 NIR-AIE 衍生物用于增强化学治疗和光动力化学联合治疗。
Eur J Med Chem. 2024 Jan 15;264:115975. doi: 10.1016/j.ejmech.2023.115975. Epub 2023 Nov 24.
4
Engineering Metal-Organic Framework Hybrid AIEgens with Tumor-Activated Accumulation and Emission for the Image-Guided GSH Depletion ROS Therapy.工程化金属-有机框架杂化 AIE gens,具有肿瘤激活积累和发射用于图像引导的 GSH 耗竭 ROS 治疗。
ACS Appl Mater Interfaces. 2022 Jul 6;14(26):29599-29612. doi: 10.1021/acsami.2c05860. Epub 2022 Jun 23.
5
Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential.具有强双光子吸收、优异细胞器特异性和高效光动力治疗潜力的明亮近红外聚集诱导发射发光体。
ACS Nano. 2018 Aug 28;12(8):8145-8159. doi: 10.1021/acsnano.8b03138. Epub 2018 Aug 7.
6
Facile and green fabrication of tumor- and mitochondria-targeted AIEgen-protein nanoparticles for imaging-guided photodynamic cancer therapy.简便绿色制备肿瘤和线粒体靶向 AIEgen-蛋白纳米颗粒用于成像引导光动力癌症治疗。
Acta Biomater. 2023 Sep 15;168:551-564. doi: 10.1016/j.actbio.2023.06.048. Epub 2023 Jul 5.
7
Dual-Functional NIR AIEgens for High-Fidelity Imaging of Lysosomes in Cells and Photodynamic Therapy.双功能近红外 AIE 探针对细胞溶酶体的高保真成像及光动力治疗
ACS Sens. 2020 Jan 24;5(1):225-233. doi: 10.1021/acssensors.9b02090. Epub 2019 Dec 30.
8
Construction of heteroaryl-bridged NIR AIEgens for specific imaging of lipid droplets and its application in photodynamic therapy.构建杂芳基桥联 NIR AIEgens 用于特异性成像脂滴及其在光动力治疗中的应用。
Spectrochim Acta A Mol Biomol Spectrosc. 2022 May 5;272:120946. doi: 10.1016/j.saa.2022.120946. Epub 2022 Jan 25.
9
A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics.一种用于高效设计靶向线粒体的近红外二区光热治疗试剂的简单策略。
J Mater Chem B. 2023 Mar 22;11(12):2700-2705. doi: 10.1039/d2tb02295h.
10
A Highly Water-Soluble Aggregation-Induced Emission Luminogen with Anion-π Interactions for Targeted NIR Imaging of Cancer Cells and Type I Photodynamic Therapy.一种具有阴离子-π 相互作用的高水溶性聚集诱导发射发光体,用于癌细胞的靶向近红外成像和 I 型光动力疗法。
Angew Chem Int Ed Engl. 2023 Aug 14;62(33):e202307776. doi: 10.1002/anie.202307776. Epub 2023 Jul 10.

引用本文的文献

1
Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics.用于先进光热诊疗的具有近红外发射的水溶性聚集诱导发光剂
Small Sci. 2023 Jul 21;3(9):2300052. doi: 10.1002/smsc.202300052. eCollection 2023 Sep.
2
Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications.基于有机分子的免洗荧光工具:设计原理与生物医学应用
Exploration (Beijing). 2024 Jun 28;5(1):20230094. doi: 10.1002/EXP.20230094. eCollection 2025 Feb.
3
Preparation of transferrin-modified IR820-loaded liposomes and its effect on photodynamic therapy of breast cancer.
转铁蛋白修饰的载IR820脂质体的制备及其对乳腺癌光动力治疗的作用
Discov Oncol. 2024 Nov 2;15(1):611. doi: 10.1007/s12672-024-01486-z.
4
Molecular engineering to design a bright near-infrared red photosensitizer: cellular bioimaging and phototherapy.用于设计明亮近红外红色光敏剂的分子工程:细胞生物成像与光疗
RSC Adv. 2024 Apr 26;14(20):13801-13807. doi: 10.1039/d4ra00928b. eCollection 2024 Apr 25.