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丙泊酚通过抑制环状 RNA-锌指 RNA 结合蛋白/微小 RNA-212-5p/超氧化物歧化酶 2 轴调节卵巢肿瘤糖酵解重编程。

Propofol modulates glycolysis reprogramming of ovarian tumor via restraining circular RNA-zinc finger RNA-binding protein/microRNA-212-5p/superoxide dismutase 2 axis.

机构信息

Department of Anesthesiology, Jinan Maternal and Child Health Hospital, Jinan City, Shandong Province, China.

Department of Anesthesiology, Qingdao Women's and Children's Hospital, Qingdao City, Shandong Province, China.

出版信息

Bioengineered. 2022 May;13(5):11881-11892. doi: 10.1080/21655979.2022.2063649.

DOI:10.1080/21655979.2022.2063649
PMID:35543376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9275929/
Abstract

Metabolic reprogramming refers to the transformation of the whole metabolic network covering glycolysis and mitochondrial metabolism, which is primarily manifested as the Warburg effect and mitochondrial metabolic reprogramming. Propofol (Pro) has been testified to suppress the malignancy of diversified human cancers. Nevertheless, its role in glycolysis is still uncertain. The purpose of this study was to determine whether Pro modulated glycolysis in ovarian cancer (OC) cells. Cell proliferation, apoptosis, migration, and invasion were tested via CCK-8, flow cytometry, and Transwell assays, respectively, and glucose intake, lactic acid, and ATP production were also determined. Pro restrained glycolysis via mediating the circular RNA-zinc finger RNA-binding protein (ZFR)/microRNA (miR)-212-5p/superoxide dismutase 2 (SOD2) axis. Additionally, Pro restrained cancer cell advancement via modulating circ-ZFR/miR-212-5p/SOD2 axis. In short, Pro restrained glycolysis via mediating the circ-ZFR/miR-212-5p/SOD2 axis. These results offered a better theoretical foundation for comprehending the molecular pathology of OC and provided a novel target for OC diagnosis and treatment.

摘要

代谢重编程是指覆盖糖酵解和线粒体代谢的整个代谢网络的转变，主要表现为沃伯格效应和线粒体代谢重编程。丙泊酚（Pro）已被证明能抑制多种人类癌症的恶性程度。然而，其在糖酵解中的作用尚不确定。本研究旨在确定 Pro 是否调节卵巢癌细胞中的糖酵解。通过 CCK-8、流式细胞术和 Transwell 分析分别检测细胞增殖、凋亡、迁移和侵袭，同时还测定葡萄糖摄取、乳酸和 ATP 产生。Pro 通过介导环状 RNA-锌指 RNA 结合蛋白（ZFR）/微小 RNA（miR）-212-5p/超氧化物歧化酶 2（SOD2）轴来抑制糖酵解。此外，Pro 通过调节 circ-ZFR/miR-212-5p/SOD2 轴来抑制癌细胞的进展。总之，Pro 通过介导 circ-ZFR/miR-212-5p/SOD2 轴来抑制糖酵解。这些结果为理解 OC 的分子病理学提供了更好的理论基础，并为 OC 的诊断和治疗提供了新的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/20ca229ff9c1/KBIE_A_2063649_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/b39d0dde61af/KBIE_A_2063649_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/771226287b6b/KBIE_A_2063649_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/2c45728b291d/KBIE_A_2063649_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/c97ba42efa2e/KBIE_A_2063649_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/896ff0af778a/KBIE_A_2063649_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/adfa787feca6/KBIE_A_2063649_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/20ca229ff9c1/KBIE_A_2063649_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/b39d0dde61af/KBIE_A_2063649_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/771226287b6b/KBIE_A_2063649_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/2c45728b291d/KBIE_A_2063649_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/c97ba42efa2e/KBIE_A_2063649_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/896ff0af778a/KBIE_A_2063649_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/adfa787feca6/KBIE_A_2063649_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2554/9275929/20ca229ff9c1/KBIE_A_2063649_F0006_OC.jpg

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