β-半乳糖苷酶激活的肝癌治疗与成像诊疗一体化。
β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging.
机构信息
Department of Science, Amrita School of Engineering, Amrita Viswa Vidyapeetham, Coimbatore, India, 641112.
School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia.
出版信息
Chem Commun (Camb). 2022 May 30;58(44):6413-6416. doi: 10.1039/d2cc01825j.
A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence imaging.
一种 β-半乳糖苷酶激活型荧光开启的治疗诊断两用 Gal-CGem，在过表达 β-半乳糖苷酶的肝癌细胞中特异性释放吉西他滨。Gal-CGem 在癌细胞中的细胞毒性是通过细胞凋亡途径实现的。总的来说，Gal-CGem 是一种新的一线抗癌前药，通过荧光成像提供了抗肿瘤信息。
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