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大分子病毒进入抑制剂作为广谱一线抗病毒药物，对 SARS-CoV-2 具有活性。

Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2.

机构信息

Institute of Molecular Virology, Ulm University Medical Center, Ulm, 89081, Germany.

Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark.

出版信息

Adv Sci (Weinh). 2022 Jul;9(20):e2201378. doi: 10.1002/advs.202201378. Epub 2022 May 11.

DOI:10.1002/advs.202201378
PMID:35543527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9284172/
Abstract

Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core-shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.

摘要

基于聚苯乙烯磺酸盐的病毒细胞进入抑制剂及其基于金纳米粒子的核壳纳米制剂被研究用于对抗一系列病毒，包括 SARS-CoV-2 的临床分离株。研究表明，大分子抑制剂具有高度理想的广谱抗病毒活性，涵盖了大多数分析的包膜病毒以及测试的所有 SARS-CoV-2 关注变体。在适当的细胞培养模型中和在小鼠中针对呼吸道病毒病原体（呼吸道合胞病毒和 SARS-CoV-2）进行了体外抑制活性的定量。本研究的结果是病毒细胞进入的大分子抑制剂沿转化途径的重要一步，特别是针对包膜呼吸道病毒。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333d/9284172/678788bbf0cf/ADVS-9-2201378-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333d/9284172/e55a2dd9ee42/ADVS-9-2201378-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333d/9284172/c1a205aefbb2/ADVS-9-2201378-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333d/9284172/48574855f946/ADVS-9-2201378-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333d/9284172/50bd4cfdb616/ADVS-9-2201378-g009.jpg
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