Clements Archie C A, Addis Alene Kefyalew
Curtin University Faculty of Health Sciences, Perth, WA, Australia; Telethon Kids Institute, Perth, WA, Australia.
Curtin University Faculty of Health Sciences, Perth, WA, Australia; Telethon Kids Institute, Perth, WA, Australia.
Lancet Microbe. 2022 Jan;3(1):e72-e79. doi: 10.1016/S2666-5247(21)00181-6. Epub 2021 Sep 28.
The global distribution and morbidity effects for each specific hookworm species is unknown, which prevents implementation of the optimum intervention for local hookworm control. We did two systematic reviews of studies on the proportion of hookworm isolates of each species and genus by region of the world and associations between hookworm species-specific infections and morbidity outcomes, particularly severe anaemia. Necator americanus and Ancylostoma spp were present in all regions of the world, although at different ratios. No clear evidence was found for the differential morbidity effects of different hookworm species. Diagnostic methods that differentiate between hookworm species, including molecular methods, need to be developed for widespread use in control programmes to elucidate key features of hookworm epidemiology and control.
每种特定钩虫物种的全球分布及发病影响尚不清楚，这阻碍了针对当地钩虫控制实施最佳干预措施。我们对关于按世界区域划分的各物种和属的钩虫分离株比例以及钩虫物种特异性感染与发病结果（尤其是严重贫血）之间关联的研究进行了两项系统评价。美洲板口线虫和钩口线虫属存在于世界所有地区，不过比例不同。未发现不同钩虫物种在发病影响方面存在差异的明确证据。需要开发包括分子方法在内的能够区分钩虫物种的诊断方法，以便在控制项目中广泛应用，从而阐明钩虫流行病学和控制的关键特征。
