From the Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Pediatr Infect Dis J. 2022 Aug 1;41(8):e318-e320. doi: 10.1097/INF.0000000000003573. Epub 2022 Jul 13.
This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction-positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Apart from the absence of fever/chills, individual symptoms did not strongly predict nonseroconversion.
本研究为前瞻性病例确认的家庭传播研究的子研究，调查了严重急性呼吸综合征冠状病毒 2 逆转录聚合酶链反应阳性但未产生抗体的个体，以及与非血清转化相关的因素。大约每 8 例 2019 年冠状病毒病患者中就有 1 例未发生血清转化。与成年人相比，儿童，尤其是年龄最小的儿童，发生血清转化的可能性约为其一半。除了没有发热/寒战外，个体症状也不能很好地预测非血清转化。
