耳鸣的药物治疗——特别论及黑色素的作用
Pharmacological treatment of tinnitus with special reference to the role of melanin.
作者信息
Lyttkens L
出版信息
Scand Audiol Suppl. 1986;26:27-31.
PMID:3554483
Abstract
Local anaesthetics have hitherto been thought to exert their effects on tinnitus through a centrally operative mechanism, analogously to their effects in epilepsy and central pain. Evidences for a peripheral mechanism, probably related to the affinity of these drugs to inner ear melanin, are reviewed. The physico-chemical properties of melanin and findings indicating that this substance plays a role in hearing are also discussed.
摘要
迄今为止，局部麻醉剂被认为是通过一种中枢作用机制对耳鸣产生影响，这类似于它们在癫痫和中枢性疼痛中的作用。本文综述了一种可能与这些药物对内耳黑色素的亲和力有关的外周机制的证据。还讨论了黑色素的物理化学性质以及表明该物质在听力中起作用的研究结果。
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