2008 - 2018年巴西1岁以下儿童百日咳发病率及其与母亲疫苗接种的关系。
Pertussis incidence in children under 1 year old and relation with maternal vaccination in Brazil, 2008-2018.
作者信息
Machado Lia Zumblick, Marcon Chaiana Esmeraldino Mendes
机构信息
Universidade do Sul de Santa Catarina, Tubarão, SC, Brasil.
出版信息
Epidemiol Serv Saude. 2022;31(1):e2021625. doi: 10.1590/S1679-49742022000100029.
OBJETIVE
To analyze the impact of maternal vaccination coverage with diphtheria-tetanus-acellular pertussis (Tdap) adsorbed vaccine for adults on pertussis incidence in children under 1 year old in Brazil from 2008 to 2018.
METHODS
This was a descriptive ecological temporal trend study using data from surveillance systems managed by the Brazilian National Health System Information Technology Department (DATASUS). Incidence rates and incidence rate ratios (IRR) were calculated with respective 95% confidence intervals (95%CI).
RESULTS
There were 20,650 pertussis cases in the study period. In the post-vaccination period there was a 26.6% reduction (IRR = 0.73; 95%CI 0.66;0.82) in pertussis incidence among children aged from 3 months up to but not including 1 year old, and a 63.6% reduction (IRR = 0.36; 95%CI 0.15;0.58) among children from birth to 2 months old.
CONCLUSION
The increase in maternal Tdap vaccination coverage coincided with a reduction in pertussis incidence, especially in the birth to two-month-old age group.
目的
分析2008年至2018年巴西成人吸附型白喉-破伤风-无细胞百日咳（Tdap）疫苗的孕产妇接种覆盖率对1岁以下儿童百日咳发病率的影响。
方法
这是一项描述性生态时间趋势研究，使用巴西国家卫生系统信息技术部（DATASUS）管理的监测系统数据。计算发病率和发病率比（IRR）以及各自的95%置信区间（95%CI）。
结果
研究期间共报告20650例百日咳病例。在接种疫苗后，3个月至未满1岁儿童的百日咳发病率降低了26.6%（IRR = 0.73；95%CI 0.66；0.82），出生至2个月龄儿童的发病率降低了63.6%（IRR = 0.36；95%CI 0.15；0.58）。
结论
孕产妇Tdap疫苗接种覆盖率的提高与百日咳发病率的降低相吻合，尤其是在出生至2个月龄的年龄组。
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