GSK, Rio de Janeiro, RJ, Brazil.
Ribeirão Preto Medical School, University of São Paulo, Brazil.
Hum Vaccin Immunother. 2020;16(1):61-69. doi: 10.1080/21645515.2019.1634991. Epub 2019 Jul 24.
We described pertussis epidemiological trends in Brazil between 2010 and 2015. We also assessed tetanus, diphtheria and acellular pertussis (Tdap) vaccine coverage among pregnant women from 2014, the year of the introduction of Tdap maternal immunization recommendation in Brazil, to 2016. Epidemiological data for incidence, prevalence, hospitalization, mortality, and maternal vaccination coverage were calculated based on the Brazilian public surveillance databases. The epidemiological data analysis results showed that the pertussis average incidence rate (IR) was 2.19/100,000 inhabitants for all ages, with a peak in 2014 (4.03/100,000 inhabitants) and highest incidence in <1-year-old children (IR = 175.20/100,000). 97.6% of pertussis deaths (405/415) were in <1-year-old children. Maternal immunization coverage was 9.2% in 2014, 40.4% in 2015, and 33.8% in 2016. Pertussis incidence and pertussis-related deaths increased in Brazil from 2010 to 2014 and decreased in 2015. In the two years, 2015 and 2016 that followed the NIP recommendation, Tdap vaccination coverage of pregnant women was low and varying from region to region. More efforts and national plans would help increase awareness and maternal immunization coverage.
我们描述了 2010 年至 2015 年巴西百日咳的流行趋势。我们还评估了 2014 年（即巴西推荐 Tdap 母亲免疫的那一年）至 2016 年期间孕妇的破伤风、白喉和无细胞百日咳（Tdap）疫苗覆盖率。发病率、患病率、住院率、死亡率和孕产妇疫苗接种覆盖率的流行病学数据是根据巴西公共监测数据库计算得出的。流行病学数据分析结果表明，所有年龄段百日咳的平均发病率（IR）为 2.19/100,000 居民，2014 年达到峰值（4.03/100,000 居民），1 岁以下儿童的发病率最高（IR=175.20/100,000）。97.6%的百日咳死亡病例（405/415）发生在<1 岁的儿童中。2014 年、2015 年和 2016 年的孕产妇免疫覆盖率分别为 9.2%、40.4%和 33.8%。2010 年至 2014 年，巴西百日咳的发病率和与百日咳相关的死亡人数增加，2015 年有所下降。在 NIP 建议后的两年，即 2015 年和 2016 年，孕妇 Tdap 疫苗接种覆盖率较低且各地区差异较大。需要做出更多努力并制定国家计划，以提高认识并增加孕产妇免疫接种率。
