School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Regen Med. 2022 Jun;17(6):401-418. doi: 10.2217/rme-2022-0029. Epub 2022 May 12.
Severe traumatic wounds and burns have a high chance of mortality and can leave survivors with many functional disabilities and cosmetic problems, including scars. The healing process requires a harmonious interplay of various cells and growth factors. Different structures of the skin house numerous cells, matrix components and growth factors. Any disturbance in the balance between these components can impair the healing process. The function of cells and growth factors can be manipulated and facilitated to aid tissue repair. In the current review, the authors focus on the importance of the skin microenvironment, the pathophysiology of various types of burns, mechanisms and factors involved in skin repair and wound healing and regeneration of the skin using tissue engineering approaches.
严重创伤和烧伤的死亡率很高，幸存者会留下许多功能障碍和美容问题，包括疤痕。愈合过程需要各种细胞和生长因子的和谐相互作用。皮肤的不同结构包含众多细胞、基质成分和生长因子。这些成分之间的平衡任何干扰都可能会损害愈合过程。细胞和生长因子的功能可以通过操纵和促进来帮助组织修复。在本次综述中，作者重点介绍了皮肤微环境的重要性、各种类型烧伤的病理生理学、皮肤修复和伤口愈合的机制和因素，以及使用组织工程方法再生皮肤。
