现在是否是关注 COVID-19 引发的炎症引发的铁介导病理学的时候了？
Is it a high time to focus on iron-mediated pathology initiated by COVID-induced inflammation?
机构信息
a:1:{s:5:"en_US";s:81:"N.M.Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow";}.
出版信息
Acta Biomed. 2022 May 11;93(2):e2022229. doi: 10.23750/abm.v93i2.13165.
Abstract
A comment to paper published in the current issue by Duca et al (Acta Biomed 2022; Vol. 93, N. 2: e2022057 - DOI 10.23750/abm.v93i2.12937 - https://mattioli1885journals.com/index.php/actabiomedica/article/view/12937). The paper demonstrated a link between deregulated iron homeostasis and hyperinflammation in nontreated COVID-19 patients. Iron homeostasis links two generally accepted COVID-initiated pathological events: hyperinflammation and abnormal fibrin clotting. Intensive research is needed to look for the ways how to support and recover FeH in COVID infected patients.
摘要
对 Duca 等人在本期发表的论文的评论（《生物医学学报》2022 年；第 93 卷，第 2 期：e2022057- DOI 10.23750/abm.v93i2.12937- https://mattioli1885journals.com/index.php/actabiomedica/article/view/12937）。该论文证明了铁稳态失调与未经治疗的 COVID-19 患者的过度炎症之间存在关联。铁稳态将两个普遍公认的 COVID 引发的病理事件联系起来：过度炎症和异常纤维蛋白凝结。需要进行深入研究，以寻找支持和恢复 COVID 感染患者铁稳态的方法。
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本文引用的文献
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Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facit.新冠病毒感染中的铁代谢失调与 SARS-CoV-2 的相互进化：自然不会徒劳无功。
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Serum ferritin levels in inflammation: a retrospective comparative analysis between COVID-19 and emergency surgical non-COVID-19 patients.血清铁蛋白水平与炎症：COVID-19 与急诊非 COVID-19 手术患者的回顾性对比分析。
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Hepcidin is a friend rather than a foe in COVID19-induced complications.在 COVID19 引发的并发症中，铁调素是朋友而非敌人。
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Hepcidin levels predict Covid-19 severity and mortality in a cohort of hospitalized Italian patients.在一组意大利住院患者中，铁调素水平可预测新冠病毒疾病的严重程度和死亡率。
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