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肝胆癌:诊断、发病机制和治疗的进展。

Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment.

机构信息

The Hormel Institute, 5635University of Minnesota, Austin, MN, USA.

Masonic Cancer Center, 5635University of Minnesota, Minneapolis, MN, USA.

出版信息

Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221097203. doi: 10.1177/15330338221097203.

DOI:10.1177/15330338221097203
PMID:35546130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9257325/
Abstract

Hepatobiliary cancers comprise a wide range of malignancies such as hepatocellular carcinoma and cholangiocarcinoma, and they are some of the most challenging to treat human neoplasms. Due to the rarity of the illnesses, the development of treatment measures for malignancies of the gastrointestinal system is far behind. The number of patients eligible for curative treatment is limited due to cancer's aggressive nature and the difficulties of early identification. Furthermore, surgery is frequently intrusive and linked with a significant level of risk. The therapy result of hepatobiliary cancers is unsatisfactory due to these complicated variables, leaving significant space for improvement.

摘要

肝胆癌包括多种恶性肿瘤,如肝细胞癌和胆管癌,它们是最难治疗的人类肿瘤之一。由于这些疾病较为罕见,胃肠道系统恶性肿瘤的治疗措施的发展远远落后。由于癌症的侵袭性和早期识别的困难,适合治愈性治疗的患者数量有限。此外,手术常常具有侵入性,并伴随着相当大的风险。由于这些复杂的变量,肝胆癌的治疗效果并不理想,还有很大的改进空间。

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Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment.肝胆癌:诊断、发病机制和治疗的进展。
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本文引用的文献

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Lenvatinib plus pembrolizumab: the next frontier for the treatment of hepatocellular carcinoma?乐伐替尼联合帕博利珠单抗:肝癌治疗的下一个前沿?
Expert Opin Investig Drugs. 2022 Apr;31(4):371-378. doi: 10.1080/13543784.2021.1948532. Epub 2021 Jun 30.
2
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.肝胆肿瘤,2.2021 年版,NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022.
3
Biochemical predictors of response to immune checkpoint inhibitors in unresectable hepatocellular carcinoma.不可切除肝细胞癌中免疫检查点抑制剂反应的生化预测因子。
Cancer Treat Res Commun. 2021;27:100328. doi: 10.1016/j.ctarc.2021.100328. Epub 2021 Feb 2.
4
Hepatocellular carcinoma.肝细胞癌。
Nat Rev Dis Primers. 2021 Jan 21;7(1):6. doi: 10.1038/s41572-020-00240-3.
5
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.胆管癌 2020:机制和管理的新前沿。
Nat Rev Gastroenterol Hepatol. 2020 Sep;17(9):557-588. doi: 10.1038/s41575-020-0310-z. Epub 2020 Jun 30.
6
Surgical Treatments of Hepatobiliary Cancers.肝胆肿瘤的外科治疗。
Hepatology. 2021 Jan;73 Suppl 1:128-136. doi: 10.1002/hep.31325. Epub 2020 Nov 26.
7
Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma.组蛋白去乙酰化酶在癌症发生中的作用:在胆管癌中的潜在作用。
Cells. 2020 Mar 23;9(3):780. doi: 10.3390/cells9030780.
8
The primary cilium: Its role as a tumor suppressor organelle.初级纤毛:作为肿瘤抑制细胞器的作用。
Biochem Pharmacol. 2020 May;175:113906. doi: 10.1016/j.bcp.2020.113906. Epub 2020 Mar 10.
9
Biomarkers for Hepatobiliary Cancers.肝胆肿瘤标志物。
Hepatology. 2021 Jan;73 Suppl 1:115-127. doi: 10.1002/hep.31175. Epub 2020 Nov 29.