步行锻炼和肠道清洁间隔对肠道准备质量的影响：一项单盲随机对照试验

Effect of Walking Exercise and Intestinal Cleansing Interval on Bowel Preparation Quality, a Single-Blind, Randomized Controlled Trial.

作者信息

Gao Xin, Bian Qiugui, Ding Wenqin, Qian Haisheng, Li Wenjie, Zhang Guoxin, Li Xuan

机构信息

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, China.

Department of Gastroenterology, Jiangsu Province Hospital, Nanjing, 210000, China.

出版信息

Dig Dis Sci. 2023 Jan;68(1):193-201. doi: 10.1007/s10620-022-07526-4. Epub 2022 May 11.

DOI:10.1007/s10620-022-07526-4

PMID:35546206

Abstract

BACKGROUND AND AIMS

High-quality intestinal preparation could promote intestinal cleanliness and lead to more accurate diagnosis, which patients will benefit from. This study aimed to explore the effectiveness of walking exercise and intestinal cleansing interval in bowel preparation before colonoscopy.

METHODS

A randomized controlled single blind study was conducted during August 2021 to February 2022. Patients requiring colonoscopy were randomly divided into three groups: 0 step, 5000 steps or 10,000 steps during the intestinal preparation. Participants took the same intestinal cleansing drugs 4-6 h prior to the procedure: 2L-dose polyethylene glycol (PEG).

RESULTS

A total of 300 patients were enrolled in the experiment (100 patients per group), and the baseline information of the three groups was close. The BBPS of right (0-step group vs 5,000-step group vs 10,000-step group: 1.78 ± 0.65 vs 1.88 ± 0.54 vs 2.36 ± 0.69, p < 0.001), transverse (0-step group vs 5,000-step group vs 10,000-step group: 2.09 ± 0.78 vs 2.18 ± 0.61 vs 2.59 ± 0.71, p < 0.001) and left (0-step group vs 5,000-step group vs 10,000-step group: 2.01 ± 0.91 vs 2.24 ± 0.59 vs 2.51 ± 0.60, p < 0.001) colon in 10,000-step group were significantly higher than others, respectively. And we also drew the same conclusion in the aspect of ADR. The adverse events and patients' satisfaction had no differences between the two groups. Moreover, intestinal cleansing interval (< 5.12 h) was only effective in BBPS of right colon (p < 0.001) and left colon (p = 0.039).

CONCLUSIONS

This study suggested that participants took 10,000-step walking exercise and took PEG 5.12 h prior to the procedure were effective in routine pre-procedure cleanout for standard colonoscopy.

NAME OF REGISTRY

Effect of starting time of bowel cleansing and walking exercise after bowel cleansing on bowel preparation: A prospective randomized controlled study.

REGISTRATION NUMBER

ChiCTR2100049214.

摘要

背景与目的

高质量的肠道准备可促进肠道清洁，从而实现更准确的诊断，患者将从中受益。本研究旨在探讨步行运动及肠道清洁间隔时间对结肠镜检查前肠道准备的效果。

方法

于2021年8月至2022年2月进行一项随机对照单盲研究。需要进行结肠镜检查的患者被随机分为三组：肠道准备期间分别行走0步、5000步或10000步。参与者在检查前4 - 6小时服用相同的肠道清洁药物：2升剂量的聚乙二醇（PEG）。

结果

共有300例患者纳入实验（每组100例），三组的基线信息相近。10000步组右半结肠（0步组 vs 5000步组 vs 10000步组：1.78 ± 0.65 vs 1.88 ± 0.54 vs 2.36 ± 0.69，p < 0.001）、横结肠（0步组 vs 5000步组 vs 10000步组：2.09 ± 0.78 vs 2.18 ± 0.61 vs 2.59 ± 0.71，p < 0.001）和左半结肠（0步组 vs 5000步组 vs 10000步组：2.01 ± 0.91 vs 2.24 ± 0.59 vs 2.51 ± 0.60，p < 0.001）的波士顿肠道准备评分（BBPS）均显著高于其他组。在不良事件方面我们也得出了相同结论。两组之间的不良事件及患者满意度无差异。此外，肠道清洁间隔时间（< 5.12小时）仅对右半结肠（p < 0.001）和左半结肠（p = 0.039）的BBPS有效。