Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Headache. 2022 Jun;62(6):718-725. doi: 10.1111/head.14320. Epub 2022 May 11.
No studies have evaluated the glymphatic system function in patients with migraine. In this pilot study, we evaluated and compared the alterations in the glymphatic system function in patients with migraine with healthy controls using a diffusion tensor imaging (DTI) analysis along the perivascular space (DTI-ALPS) method. We also investigated the differences in the glymphatic system function table between patients with migraine with and without aura using the ALPS method.
This field study used a cross-sectional study design. We prospectively enrolled patients with migraine and healthy controls. All brain magnetic resonance imaging (MRI), including DTI, in participants, patients with migraine, and healthy controls were obtained using the same MRI scanner. We calculated and compared the ALPS index between patients with migraine and healthy controls, and between patients with migraine with and without aura. In addition, we investigated the association between the glymphatic system function and the clinical characteristics of migraine.
We enrolled 92 patients with migraine and 80 healthy controls. There were no significant differences in the ALPS index between patients with migraine and healthy controls (1.655 ± 0.335 [patients with migraine] vs. 1.713 ± 0.297 [controls], difference = 0.058, 95% confidence interval [CI] of difference = -0.037 to 0.154, p = 0.233), and between patients with migraine with and without aura (1.690 ± 0.380 [with aura] vs. 1.645 ± 0.323 [without aura], difference = -0.044, 95% CI of difference = -0.213 to 0.124, p = 0.601). There was no significant correlation between the ALPS index and clinical characteristics of migraine, including age (r = -0.07, p = 0.507), age at onset (r = 0.07, p = 0.552), disease duration (r = -0.12, p = 0.306), attack frequency (r = -0.05, p = 0.668), and headache intensity (r = 0.00, p = 0.976).
There was no glymphatic system dysfunction in patients with migraine. Moreover, there were no differences in the glymphatic system function between patients with migraine with and without aura. We also demonstrated the feasibility of the ALPS method, which can be used for research on various neurological diseases. Further studies are needed to confirm our findings.
目前尚无研究评估偏头痛患者的糖质液系统功能。在本初步研究中，我们采用弥散张量成像（DTI）分析沿血管周围空间（DTI-ALPS）的方法，评估并比较了偏头痛患者与健康对照者糖质液系统功能的改变。我们还使用 ALPS 方法比较了偏头痛伴和不伴先兆患者的糖质液系统功能表之间的差异。
本现场研究采用横断面研究设计。我们前瞻性招募偏头痛患者和健康对照者。所有参与者、偏头痛患者和健康对照者的脑磁共振成像（MRI）均包括 DTI，均使用相同的 MRI 扫描仪获得。我们计算并比较了偏头痛患者与健康对照者之间以及偏头痛伴和不伴先兆患者之间的 ALPS 指数。此外，我们还研究了糖质液系统功能与偏头痛临床特征之间的关系。
我们共纳入 92 例偏头痛患者和 80 例健康对照者。偏头痛患者的 ALPS 指数与健康对照者无显著差异（1.655±0.335[偏头痛患者]vs.1.713±0.297[对照组]，差异=0.058，95%置信区间[CI]差值=-0.037 至 0.154，p=0.233），偏头痛伴和不伴先兆患者的 ALPS 指数也无显著差异（1.690±0.380[伴先兆]vs.1.645±0.323[无先兆]，差异=-0.044，95%CI 差值=-0.213 至 0.124，p=0.601）。ALPS 指数与偏头痛的临床特征（包括年龄[r=-0.07，p=0.507]、发病年龄[r=0.07，p=0.552]、病程[r=-0.12，p=0.306]、发作频率[r=-0.05，p=0.668]和头痛强度[r=0.00，p=0.976]）均无显著相关性。
偏头痛患者的糖质液系统无功能障碍。此外，偏头痛伴和不伴先兆患者的糖质液系统功能无差异。我们还证实了 ALPS 方法的可行性，该方法可用于各种神经疾病的研究。需要进一步的研究来证实我们的发现。
