Department of Neurology, Tufts Medical Center, Boston, MA, USA.
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Curr Neurol Neurosci Rep. 2024 Oct;24(10):517-525. doi: 10.1007/s11910-024-01368-5. Epub 2024 Aug 16.
We aim to critically review animal and human studies of the glymphatic system in migraine and propose a model for how the glymphatic system may function in migraine, based on the available evidence.
Early studies in animal models report migraine attacks temporarily disrupt glymphatic flow. Human imaging studies suggest chronic migraine may be associated with alterations in glymphatic system function, albeit with conflicting results. Presently, it remains unknown whether repetitive migraine attacks or frequent nights of insomnia impair glymphatic system function over time in those with migraine, and whether alterations in glymphatic function could contribute to worsening migraine disability or risk for cognitive disease. Longitudinal studies of glymphatic function in patients with migraine and insomnia, with inclusion of cognitive assessments, may be informative.
我们旨在批判性地回顾偏头痛中糖质分解系统的动物和人体研究，并根据现有证据提出糖质分解系统在偏头痛中可能发挥作用的模型。
早期动物模型研究报告偏头痛发作会暂时破坏糖质分解系统的流动。人类影像学研究表明，慢性偏头痛可能与糖质分解系统功能的改变有关，但结果存在矛盾。目前，尚不清楚偏头痛患者反复发作偏头痛或经常失眠是否会随着时间的推移而损害糖质分解系统的功能，以及糖质分解功能的改变是否会导致偏头痛残疾恶化或认知疾病的风险增加。对偏头痛和失眠患者的糖质分解功能进行纵向研究，包括认知评估，可能会有所帮助。
