偏头痛患者异常的糖脂系统功能：一项扩散峰度成像研究。
Abnormally glymphatic system functional in patients with migraine: a diffusion kurtosis imaging study.
机构信息
Department of Neurology of the Second Affiliated Hospital, Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Department of Radiology of the Second Affiliated Hospital, Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
出版信息
J Headache Pain. 2024 Jul 22;25(1):118. doi: 10.1186/s10194-024-01825-z.
BACKGROUND
The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since the diffusion tensor model cannot accurately describe the diffusion coefficient of the nerve fibre crossing region, we proposed a diffusion kurtosis imaging ALPS (DKI-ALPS) method to evaluate glymphatic system function in patients with migraine.
METHODS
The study included 29 healthy controls and 37 patients with migraine. We used diffusion imaging data from a 3T MRI scanner to calculate DTI-ALPS and DKI-ALPS indices of the two groups. We compared the DTI-ALPS and DKI-ALPS indices between the two groups using a two-sample t-test and performed correlation analyses with clinical variables.
RESULTS
There was no significant difference in DTI-ALPS index between the two groups. Patients with migraine showed a significantly increased right DKI-ALPS index compared to healthy controls (1.6858 vs. 1.5729; p = 0.0301). There was no significant correlation between ALPS indices and clinical variables.
CONCLUSIONS
DKI-ALPS is a potential method to assess glymphatic system function and patients with migraine do not have impaired glymphatic system function.
背景
沿血管周围空间的扩散张量成像分析（DTI-ALPS）方法已被用于评估偏头痛患者的糖脂系统功能。然而，由于扩散张量模型不能准确描述神经纤维交叉区域的扩散系数，我们提出了一种扩散峰度成像 ALPS（DKI-ALPS）方法来评估偏头痛患者的糖脂系统功能。
方法
该研究纳入了 29 名健康对照者和 37 名偏头痛患者。我们使用来自 3T MRI 扫描仪的扩散成像数据来计算两组的 DTI-ALPS 和 DKI-ALPS 指数。我们使用两样本 t 检验比较两组之间的 DTI-ALPS 和 DKI-ALPS 指数，并与临床变量进行相关性分析。
结果
两组间 DTI-ALPS 指数无显著差异。偏头痛患者的右 DKI-ALPS 指数明显高于健康对照组（1.6858 比 1.5729；p=0.0301）。ALPS 指数与临床变量之间无显著相关性。
结论
DKI-ALPS 是一种评估糖脂系统功能的潜在方法，偏头痛患者的糖脂系统功能未受损。
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