阿达木单抗诱导的狼疮性肾炎：病例报告及文献综述

Adalimumab-Induced Lupus Nephritis: Case Report and Review of the Literature.

作者信息

Kazzi Brigitte, Gudenkauf Brent, Fine Derek, Monroy-Trujillo Jose Manuel, Azar Antoine, Giannini Gabriel, Timlin Homa

机构信息

Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA.

Division of Nephrology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA.

出版信息

Eur J Rheumatol. 2022 Apr;9(2):108-110. doi: 10.5152/eurjrheum.2022.21059.

DOI:10.5152/eurjrheum.2022.21059

PMID:35546334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10176219/

Abstract

Tumor necrosis factor-alpha inhibitors are known causative agents of systemic lupus erythemato- sus but have rarely been implicated in lupus nephritis. A patient with Crohn's disease on long-term adalimumab treatment presented with new-onset Raynaud's phenomenon and was found to have hematuria and proteinuria. Elevated antinuclear, anti-dsDNA, and MPO antibodies were found. A renal biopsy confirmed the diagnosis of lupus nephritis. Adalimumab was discontinued ensuing improvement in urine studies and resolution of dsDNA and MPO antibodies. Adalimumab can induce systemic lupus erythematosus and lupus nephritis.

摘要

肿瘤坏死因子-α抑制剂是系统性红斑狼疮的已知致病因素，但很少与狼疮性肾炎有关。一名长期接受阿达木单抗治疗的克罗恩病患者出现新发雷诺现象，并被发现有血尿和蛋白尿。发现抗核抗体、抗双链DNA抗体和髓过氧化物酶抗体升高。肾活检确诊为狼疮性肾炎。停用阿达木单抗后，尿液检查有所改善，双链DNA和髓过氧化物酶抗体水平下降。阿达木单抗可诱发系统性红斑狼疮和狼疮性肾炎。