系统性红斑狼疮中的IgM抗双链DNA抗体：与肾炎呈负相关。SLE研究组

IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. SLE Study Group.

作者信息

Witte T, Hartung K, Sachse C, Matthias T, Fricke M, Deicher H, Kalden J R, Lakomek H J, Peter H H, Schmidt R E

机构信息

Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany.

出版信息

Rheumatol Int. 1998;18(3):85-91. doi: 10.1007/s002960050063.

DOI:10.1007/s002960050063

PMID:9833247

Abstract

Antibodies against dsDNA of the IgM class were measured in sera of 352 patients with systemic lupus erythematosus, 81 blood donors and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgM anti-dsDNA antibodies were found in 52.3% of the sera from patients with systemic lupus erythematosus, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 37 laboratory parameters was calculated. There was a highly significant negative correlation between IgM anti-dsDNA antibodies and nephritis as well as all the laboratory parameters indicating renal disease (elevated serum creatinine concentration, proteinuria, erythrocyte casts in the urine). IgM anti-dsDNA antibodies indicate protection of lupus patients against the development of lupus nephritis. Further experiments will show whether application of IgM anti-dsDNA antibodies is effective in treating lupus nephritis.

摘要

采用一种以人重组双链DNA为抗原的新型酶联免疫吸附测定法（ELISA），检测了352例系统性红斑狼疮患者、81例献血者及189例类风湿关节炎患者血清中的IgM类抗双链DNA抗体。在系统性红斑狼疮患者的血清中，52.3%检测到IgM抗双链DNA抗体，但81例正常对照者及189例类风湿关节炎患者的血清中均未检测到。计算了这些自身抗体与31项临床指标和37项实验室指标之间的相关性。IgM抗双链DNA抗体与肾炎以及所有提示肾脏疾病的实验室指标（血清肌酐浓度升高、蛋白尿、尿中红细胞管型）之间存在高度显著的负相关。IgM抗双链DNA抗体表明狼疮患者对狼疮肾炎的发生具有保护作用。进一步的实验将表明应用IgM抗双链DNA抗体治疗狼疮肾炎是否有效。