Department of Neurosurgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA.
Department of Radiation Oncology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA.
J Neurooncol. 2022 Jul;158(3):393-403. doi: 10.1007/s11060-022-04026-3. Epub 2022 May 11.
Radiation is a mainstay of treatment for central nervous system (CNS) tumors. Brachytherapy involves the placement of a localized/interstitial radiation source into a tumor or resection bed and has distinct advantages that can make it an attractive form of radiation when used in the appropriate setting. However, the data supporting use of brachytherapy is clouded by variability in radiation sources, techniques, delivered doses, and trial designs. The goal of this manuscript is to identify consistent themes, review the highest-level evidence and potential indications for brachytherapy in CNS tumors, as well as highlight avenues for future work. Improved understanding of the underlying biology, indications, complications, and evolving industry-academic collaborations, place brachytherapy on the brink of a resurgence.
辐射是中枢神经系统 (CNS) 肿瘤治疗的主要手段。近距离放疗涉及将局部/间质放射源放置在肿瘤或切除部位，并且具有独特的优势，当在适当的环境中使用时，它可能成为一种有吸引力的放射形式。然而，支持近距离放疗使用的数据因放射源、技术、给予剂量和试验设计的可变性而受到影响。本文的目的是确定一致的主题，回顾 CNS 肿瘤中近距离放疗的最高级别证据和潜在适应证，并强调未来工作的方向。对基础生物学、适应证、并发症以及不断发展的行业-学术合作的深入了解，使近距离放疗处于复兴的边缘。
