First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland).
Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland).
Med Sci Monit. 2022 May 12;28:e935273. doi: 10.12659/MSM.935273.
BACKGROUND The association between patients' serum uric acid (SUA) levels and sex in atrial fibrillation (AF) remains controversial. This retrospective study from a single center in China aimed to evaluate the association between sex and SUA levels in 950 patients with AF. MATERIAL AND METHODS We retrospectively analyzed clinical information of 1913 consecutive hospitalized patients (male/female: 949/964, 68.26±11.02 years). The sample of 950 patients with AF served as the AF group and 963 age- and sex-matched patients without AF with sinus rhythm served as controls. The uricase method was used to determine SUA levels. The analysis of variance, t test, and chi-squared test were performed to analyze clinical baseline data. Pearson correlation analysis was performed to identify interrelationships and multivariate regression analysis was performed to determine the independent risk factor for AF. RESULTS SUA levels in the AF group were significantly higher in both sexes (P<0.05), especially for permanent AF. In patients with AF, SUA levels were positively correlated with serum creatinine (r=0.235, P<0.05) and prealbumin (r=0.129, P<0.05) and were negatively correlated with high-density lipoprotein cholesterol (r=-0.207, P<0.05) and apolipoprotein A1 (r=-0.167, P<0.05). SUA was independently associated with AF after adjusting for confounding factors (OR=1.244, 95% CI: 1.133-1.365, P<0.05). CONCLUSIONS In both sexes, increased SUA was significantly associated with AF. These findings supported the importance of monitoring SUA levels in patients with AF and other cardiac diseases.
血清尿酸（SUA）水平与心房颤动（AF）患者性别之间的关系仍存在争议。本研究旨在评估中国单中心的 950 例 AF 患者中性别与 SUA 水平之间的关系。
回顾性分析 1913 例连续住院患者（男/女：949/964，68.26±11.02 岁）的临床资料。950 例 AF 患者为 AF 组，963 例年龄和性别匹配的窦性心律无 AF 患者为对照组。采用尿酸酶法测定 SUA 水平。采用方差分析、t 检验和卡方检验分析临床基线资料。采用 Pearson 相关分析识别相互关系，采用多元回归分析确定 AF 的独立危险因素。
男女 AF 组 SUA 水平均显著升高（均 P<0.05），尤其在永久性 AF 患者中更为显著。在 AF 患者中，SUA 水平与血清肌酐（r=0.235，P<0.05）和前白蛋白（r=0.129，P<0.05）呈正相关，与高密度脂蛋白胆固醇（r=-0.207，P<0.05）和载脂蛋白 A1（r=-0.167，P<0.05）呈负相关。校正混杂因素后，SUA 与 AF 独立相关（OR=1.244，95%CI：1.133-1.365，P<0.05）。
男女患者中，SUA 升高与 AF 显著相关。这些发现支持在 AF 及其他心脏疾病患者中监测 SUA 水平的重要性。
