通过二氟碘烷（III）试剂实现的喹喔啉酮与烯烃的光诱导三组分二氟烷基化反应。
Photoinduced Three-Component Difluoroalkylation of Quinoxalinones with Alkenes via Difluoroiodane(III) Reagents.
作者信息
Zhou Ningning, Liu Ruiyue, Zhang Chunmeng, Wang Kun, Feng Jiaxu, Zhao Xia, Lu Kui
机构信息
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science &Technology, Tianjin 300457, China.
College of Chemistry, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Tianjin Normal University, Tianjin 300387, China.
出版信息
Org Lett. 2022 May 20;24(19):3576-3581. doi: 10.1021/acs.orglett.2c01358. Epub 2022 May 12.
An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine(III) reagents is disclosed. The new designed difluoroiodane(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxaline-2(1)-ones in moderate to excellent yields under mild conditions. Experimental studies demonstrated that a difluoroalkyl radical intermediate was involved in this reaction.
公开了一种用于喹喔啉酮、烯烃和高价碘（III）试剂之间光催化三组分反应的环境友好策略。新设计的二氟碘烷（III）试剂表现出优异的反应活性，在温和条件下以中等至优异的产率提供了多种二氟烷基取代的喹喔啉-2（1）-酮。实验研究表明该反应涉及二氟烷基自由基中间体。
Zotero 插件