喹喔啉-2(1H)-酮的 C-H 直接官能团化的最新进展：多组分串联反应。

Recent Developments in Direct C-H Functionalization of Quinoxalin-2(1)-Ones via Multi-Component Tandem Reactions.

机构信息

Guizhou Provincial Key Laboratory of Coal Clean Utilization, School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, China.

Henan Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.

出版信息

Molecules. 2023 Mar 9;28(6):2513. doi: 10.3390/molecules28062513.

DOI:10.3390/molecules28062513

PMID:36985484

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10052782/

Abstract

The direct C-H multifunctionalization of quinoxalin-2(1)-ones via multicomponent reactions has attracted considerable interest due to their diverse biological activities and chemical profile. This review will focus on recent achievements. It mainly covers reaction methods for the simultaneous introduction of C-C bonds and C-R/C/O/N/Cl/S/D bonds into quinoxalin-2(1)-ones and their reaction mechanisms. Meanwhile, future developments of multi-component reactions of quinoxalin-2(1)-ones are envisaged, such as the simultaneous construction of C-C and C-B/SI/P/F/I/SE bonds through multi-component reactions; the construction of fused ring and macrocyclic compounds; asymmetric synthesis; green chemistry; bionic structures and other fields. The aim is to enrich the methods for the reaction of quinoxalin-2(1)-ones at the C3 position, which have rich applications in materials chemistry and pharmaceutical pharmacology.

摘要

由于喹喔啉-2(1H)-酮具有多样的生物活性和化学特征，其通过多组分反应进行的 C-H 多功能化直接反应引起了相当大的关注。本综述将重点关注最近的成果。它主要涵盖了同时向喹喔啉-2(1H)-酮中引入 C-C 键和 C-R/C/O/N/Cl/S/D 键的反应方法及其反应机理。同时，预计喹喔啉-2(1H)-酮的多组分反应将有未来的发展，例如通过多组分反应同时构建 C-C 和 C-B/SI/P/F/I/SE 键；构建稠环和大环化合物；不对称合成；绿色化学；仿生结构等领域。其目的是丰富喹喔啉-2(1H)-酮在 C3 位置的反应方法，这些方法在材料化学和药物药理学中有丰富的应用。