Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Department of Orthopedics, The First People's Hospital of Tianshui City, Tianshui, China.
Curr Mol Med. 2023;23(4):350-357. doi: 10.2174/1566524022666220511123625.
The process of tissue damage, repair, and regeneration in the skeletal muscle system involves complex inflammatory processes. Factors released in the inflammatory microenvironment can affect the phenotypic changes of macrophages, thereby changing the inflammatory process, making macrophages an important target for tissue repair treatment. Mesenchymal stem cells exert anti-inflammatory effects by regulating immune cells. In particular, exosomes secreted by mesenchymal stem cells have become a new cell-free treatment strategy due to their low tumorigenicity and immunogenicity. This article focuses on the mechanism of the effect of exosomes derived from mesenchymal stem cells on the phenotype of macrophages after skeletal muscle system injury and explores the possible mechanism of macrophages as potential therapeutic targets after tissue injury.
骨骼肌系统损伤、修复和再生过程涉及复杂的炎症过程。炎症微环境中释放的因子可以影响巨噬细胞的表型变化，从而改变炎症过程，使巨噬细胞成为组织修复治疗的重要靶点。间充质干细胞通过调节免疫细胞发挥抗炎作用。特别是，间充质干细胞分泌的外泌体由于其低致瘤性和免疫原性，已成为一种新的无细胞治疗策略。本文重点介绍了间充质干细胞来源的外泌体对骨骼肌系统损伤后巨噬细胞表型的影响机制，并探讨了巨噬细胞作为组织损伤后潜在治疗靶点的可能机制。
