Hubei Engineering Research Center for Fragrant Plants, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, Hubei, 437100, P.R. China.
Hubei Provincial Institute for Food Supervision and Test, Wuhan, Hubei 430070, P.R. China.
Curr Top Med Chem. 2022;22(17):1393-1405. doi: 10.2174/1568026622666220511155442.
Cancer is a long-term and deadly pandemic that affects nearly a third of the world's population. Chemotherapy is currently the most common therapeutic treatment, but it is difficult to achieve satisfactory efficacy due to drug resistance and adverse effects.Natural products are becoming increasingly popular in cancer therapy due to their potent broad-spectrum anticancer potency and slight side effects. Lignans are complex diphenolic compounds comprising a family of secondary metabolites existing widely in plants. Naturally occurring lignans have the potential to act on cancer cells by a range of mechanisms of action and could inhibit the colony formation, arrest the cell cycle in different phases, induce apoptosis, and suppress migration, providing privileged scaffolds for the discovery of novel anticancer agents. In recent five years, a variety of naturally occurring lignans have been isolated and screened for their in vitro and/or in vivo anticancer efficacy, and some of them exhibited promising potential. This review has systematically summarized the resources, anticancer activity, and mechanisms of action of naturally occurring lignans, covering articles published between January 2017 and January 2022.
癌症是一种长期且致命的大流行病，影响了全球近三分之一的人口。化疗目前是最常见的治疗方法，但由于耐药性和副作用，难以达到令人满意的疗效。由于具有强大的广谱抗癌活性和轻微的副作用，天然产物在癌症治疗中的应用越来越受到关注。木脂素是一种复杂的二酚类化合物，是广泛存在于植物中的一类次生代谢产物。天然存在的木脂素可以通过多种作用机制作用于癌细胞，抑制集落形成，使细胞周期在不同阶段停滞，诱导细胞凋亡，抑制迁移，为发现新型抗癌药物提供了有利的支架。在过去五年中，已经分离并筛选了多种天然木脂素，以评估其体外和/或体内的抗癌功效，其中一些表现出了有前景的潜力。本综述系统地总结了天然木脂素的资源、抗癌活性和作用机制，涵盖了 2017 年 1 月至 2022 年 1 月期间发表的文章。
