College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, China.
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University , Nanchang 330022, China.
Chem Rev. 2017 Jul 12;117(13):9016-9085. doi: 10.1021/acs.chemrev.6b00620. Epub 2017 Jun 22.
Research and industrial interest in radical C-H activation/radical cross-coupling chemistry has continuously grown over the past few decades. These reactions offer fascinating and unconventional approaches toward connecting molecular fragments with high atom- and step-economy that are often complementary to traditional methods. Success in this area of research was made possible through the development of photocatalysis and first-row transition metal catalysis along with the use of peroxides as radical initiators. This Review provides a brief and concise overview of the current status and latest methodologies using radicals or radical cations as key intermediates produced via radical C-H activation. This Review includes radical addition, radical cascade cyclization, radical/radical cross-coupling, coupling of radicals with M-R groups, and coupling of radical cations with nucleophiles (Nu).
过去几十年里，自由基 C-H 活化/自由基交叉偶联化学的研究和工业兴趣持续增长。这些反应提供了引人入胜和非传统的方法，以高原子经济性和步骤经济性连接分子片段，通常与传统方法互补。通过光催化和第一过渡金属催化的发展以及过氧化物作为自由基引发剂的使用，这一领域的研究取得了成功。本文简要概述了通过自由基 C-H 活化生成关键中间体自由基或自由基阳离子的最新方法学进展，包括自由基加成、自由基级联环化、自由基/自由基交叉偶联、自由基与 M-R 基团的偶联以及自由基阳离子与亲核试剂（Nu）的偶联。
