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高效一步微波辅助合成结构多样的双取代α-氨基酸衍生二酰亚胺。

Highly efficient one-step microwave-assisted synthesis of structurally diverse bis-substituted α-amino acid derived diimides.

作者信息

Konopka Marcin, Markiewicz Grzegorz, Stefankiewicz Artur R

机构信息

Faculty of Chemistry, Adam Mickiewicz University Umultowska 89b 61-614 Poznań Poland

Center for Advanced Technologies, Adam Mickiewicz University Umultowska 89c 61-614 Poznań Poland.

出版信息

RSC Adv. 2018 Aug 23;8(52):29840-29846. doi: 10.1039/c8ra05835k. eCollection 2018 Aug 20.

DOI:10.1039/c8ra05835k
PMID:35547322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9085299/
Abstract

We report herein a facile and widely applicable microwave-assisted protocol for the synthesis of symmetrical diimides based on three structurally distinct aromatic dianhydrides: pyromellitic (PMA), biphenyl-tetracarboxylic acid (BPDA) and benzophenone-tetracarboxylic (BTDA) and five natural amino acids (Phe, Tyr, Ile, Lys, Cys). Fifteen symmetrical diimides with different structural characteristics containing a variety of functional groups can be produced with high yields and on a large scale.

摘要

我们在此报告一种简便且广泛适用的微波辅助方法，用于基于三种结构不同的芳香二酐：均苯四甲酸（PMA）、联苯四羧酸（BPDA）和二苯甲酮四羧酸（BTDA）以及五种天然氨基酸（苯丙氨酸、酪氨酸、异亮氨酸、赖氨酸、半胱氨酸）合成对称二酰亚胺。可以高产率且大规模地制备出十五种具有不同结构特征且含有多种官能团的对称二酰亚胺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/635369ba9b52/c8ra05835k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/24b6083795aa/c8ra05835k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/bac3a6e39040/c8ra05835k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/635369ba9b52/c8ra05835k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/24b6083795aa/c8ra05835k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/bac3a6e39040/c8ra05835k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e2/9085299/635369ba9b52/c8ra05835k-f2.jpg

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