Alkurt Ertugrul G, Durak Dogukan, Turhan Veysel Barış, Sahiner Ibrahim Tayfun
General Surgery, Hitit University Corum Erol Olcok Training and Research Hospital, Corum, TUR.
Cureus. 2022 Apr 9;14(4):e23972. doi: 10.7759/cureus.23972. eCollection 2022 Apr.
The ratio of c-reactive protein-to-albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer. The purpose of this study was to investigate the effect of CRP/Alb ratios on prognosis in gastric cancers.
This study included a retrospective review of a total of 147 patients with locally advanced gastric cancer. Mean platelet volume (MPV) was analyzed statistically to find a prognostic relationship between monocyte/lymphocyte ratio, platelet distribution volume (PDW), MPV/platelet, c-reactive protein/albumin ratio (CAR), and gastric cancer. Patients were staged according to the American Joint Cancer Committee (AJCC) Staging Guidelines.
The CRP/Alb ratio was independently associated with overall survival (OS) in patients with gastric cancer (GC). The CAR was above 0.25 in 52.7% (77) of the patients and below 0.25 in 47.3% (69) of the patients. Patients under 0.25 had statistically longer survival rates.
A high preoperative CAR value could predict poor prognosis in locally advanced gastric patients. The same predictive value was not observed in other hematological parameters. This simple and cost-effective ratio can be used as a clinically accessible biomarker to assist clinicians in determining future treatment plans.
C反应蛋白与白蛋白比值（CRP/Alb）是全身炎症反应的生化标志物，与癌症患者的不良生存相关。本研究旨在探讨CRP/Alb比值对胃癌预后的影响。
本研究对147例局部晚期胃癌患者进行了回顾性分析。对平均血小板体积（MPV）进行统计学分析，以寻找单核细胞/淋巴细胞比值、血小板分布宽度（PDW）、MPV/血小板、C反应蛋白/白蛋白比值（CAR）与胃癌之间的预后关系。患者根据美国癌症联合委员会（AJCC）分期指南进行分期。
CRP/Alb比值与胃癌（GC）患者的总生存期（OS）独立相关。52.7%（77例）患者的CAR高于0.25，47.3%（69例）患者的CAR低于0.25。CAR低于0.25的患者生存时间在统计学上更长。
术前高CAR值可预测局部晚期胃癌患者的预后不良。在其他血液学参数中未观察到相同的预测价值。这种简单且具有成本效益的比值可作为一种临床可用的生物标志物，帮助临床医生确定未来的治疗方案。
