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通过等离子体电解氧化和磷酸钙沉积对镁金属进行电化学表面工程：生物相容性和降解研究。

Electrochemical surface engineering of magnesium metal by plasma electrolytic oxidation and calcium phosphate deposition: biocompatibility and degradation studies.

作者信息

Kannan M Bobby, Walter R, Yamamoto A, Khakbaz H, Blawert C

机构信息

Biomaterials and Engineering Materials (BEM) Laboratory, College of Science and Engineering, James Cook University Townsville Queensland 4811 Australia

Research Center for Functional Materials, National Institute for Materials Science (NIMS) Tsukuba Ibaraki 305-0044 Japan.

出版信息

RSC Adv. 2018 Aug 16;8(51):29189-29200. doi: 10.1039/c8ra05278f. eCollection 2018 Aug 14.

DOI:10.1039/c8ra05278f
PMID:35548009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9084472/
Abstract

In this study, the surface of magnesium metal was electrochemically engineered for enhanced biocompatibility and controlled degradation in body fluid. Firstly, a plasma electrolytic oxidation (PEO) coating was formed on magnesium, followed by electrochemical deposition of calcium phosphate (CaP) using an unconventional electrolyte. Cytocompatibility tests using L929 cells revealed that the PEO-CaP coating significantly improved the biocompatibility of magnesium. electrochemical degradation experiments in simulated body fluid (SBF) showed that the PEO-CaP coating improved the degradation resistance of magnesium significantly. The corrosion current density ( ) of the PEO-CaP coated magnesium was ∼99% and ∼97% lower than that of bare magnesium and the PEO-only coated magnesium, respectively. Similarly, electrochemical impedance spectroscopy (EIS) results showed that the polarisation resistance ( ) of the PEO-CaP coated magnesium was one-order of magnitude higher as compared to the PEO-only coated magnesium and two-orders of magnitude higher than the bare magnesium, after 72 h immersion in SBF. Scanning electron microscopy (SEM) analysis revealed no localized degradation in the PEO-CaP coated magnesium. The study demonstrated that the PEO-CaP coating is a promising combination for enhancing the biocompatibility and reducing the degradation of magnesium for potential biodegradable implant applications.

摘要

在本研究中，对镁金属表面进行了电化学处理，以提高其生物相容性并控制在体液中的降解。首先，在镁表面形成等离子体电解氧化（PEO）涂层，然后使用非常规电解质电化学沉积磷酸钙（CaP）。使用L929细胞进行的细胞相容性测试表明，PEO-CaP涂层显著提高了镁的生物相容性。在模拟体液（SBF）中进行的电化学降解实验表明，PEO-CaP涂层显著提高了镁的抗降解性。PEO-CaP涂层镁的腐蚀电流密度（ ）分别比裸镁和仅涂覆PEO的镁低约99%和约97%。同样，电化学阻抗谱（EIS）结果表明，在SBF中浸泡72小时后，PEO-CaP涂层镁的极化电阻（ ）比仅涂覆PEO的镁高一个数量级，比裸镁高两个数量级。扫描电子显微镜（SEM）分析表明，PEO-CaP涂层镁没有局部降解。该研究表明，PEO-CaP涂层是一种有前景的组合，可用于增强镁的生物相容性并减少其降解，以用于潜在的可生物降解植入物应用。

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