Weinzierl Andrea, Ampofo Emmanuel, Menger Michael D, Laschke Matthias W
Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany.
Front Pharmacol. 2022 Apr 25;13:864351. doi: 10.3389/fphar.2022.864351. eCollection 2022.
Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia-reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms.
尽管术前进行了精心规划，但手术皮瓣仍易发生缺血性组织损伤和缺血再灌注损伤。由此导致的伤口裂开和皮瓣坏死增加了治疗成本和患者的发病率。因此，需要采取策略来促进皮瓣存活并预防缺血性组织损伤。植物化学物质被定义为非必需的、具有生物活性的植物衍生分子，是围手术期治疗的有吸引力的候选物，因为它们几乎没有副作用，并且大多数患者耐受性良好。此外，它们已被证明具有促血管生成、抗炎、抗氧化和抗凋亡作用的有益组合。本综述概述了在临床前动物模型中用于提高皮瓣存活率的生物活性植物化学物质，并讨论了潜在的分子和细胞机制。
