Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Research Center of Traditional Chinese Medicine, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Front Cell Infect Microbiol. 2022 Apr 25;12:853981. doi: 10.3389/fcimb.2022.853981. eCollection 2022.
Panax ginseng, as the king of Chinese herb, has significant therapeutic effects on obesity, type 2 diabetes mellitus, fatty liver disease, colitis, diarrhea, and many other diseases. This review systematically summarized recent findings, which show that ginseng plays its role by regulating gut microbiota diversity, and gut microbiota could also regulate the transformation of ginsenosides. We conclude the characteristics of ginseng in regulating gut microbiota, as the potential targets to prevent and treat metabolic diseases, colitis, neurological diseases, cancer, and other diseases. Ginseng treatment can increase some probiotics such as , , , , and reduce pathogenic bacteria such as , , against various diseases. Meanwhile, , , and were found to be the key bacteria for ginsenoside transformation . Overall, ginseng can regulate gut microbiome diversity, further affect the synthesis of secondary metabolites, as well as promote the transformation of ginsenosides for improving the absorptivity of ginsenosides. This review can provide better insight into the interaction of ginseng with gut microbiota in multiple disorders and ginsenoside transformation.
人参作为“百草之王”，对肥胖、2 型糖尿病、脂肪肝、结肠炎、腹泻等多种疾病具有显著的治疗作用。本综述系统总结了近年来的研究发现，人参通过调节肠道微生物多样性发挥作用，而肠道微生物也可以调节人参皂苷的转化。我们总结了人参调节肠道微生物的特点，作为预防和治疗代谢性疾病、结肠炎、神经退行性疾病、癌症等疾病的潜在靶点。人参治疗可以增加一些益生菌，如 、 、 、 ，减少一些致病菌，如 、 、 ，对各种疾病都有作用。同时发现 、 、 是人参皂苷转化的关键细菌。总的来说，人参可以调节肠道微生物多样性，进一步影响次生代谢物的合成，并促进人参皂苷的转化，提高人参皂苷的吸收率。本综述可以更深入地了解人参在多种疾病中的作用以及人参皂苷的转化。
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