Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
The Critical Kidney Disease Research Center of Central South University, Changsha, China.
BMC Microbiol. 2024 Sep 28;24(1):377. doi: 10.1186/s12866-024-03539-3.
The concept of the gut-kidney axis is gaining significant attention due to the close relationship between gut microbiota and kidney disease. Peritoneal dialysis is recognized as a crucial renal replacement therapy for end-stage renal disease (ESRD). The alterations in gut microbiota and related mechanisms after receiving this dialysis method are not fully understood. This study conducted shotgun metagenomic sequencing on fecal samples from 11 end-stage renal disease patients who did not receive dialysis (ESRD_N) and 7 patients who received peritoneal dialysis (ESRD_P). After quality control and correlation analysis of the data, our study is aimed at exploring the impact of peritoneal dialysis on the gut microbiota and health of ESRD patients. Our research findings indicate that the complexity and aggregation characteristics of gut microbiota interactions increase in ESRD_P. In addition, the gut microbiota drives the biosynthesis pathways of sesquiterpenes and triterpenes in ESRD_P patients, which may contribute to blood purification and improve circulation. Therefore, our research will lay the foundation for the prevention and treatment of ESRD.
肠-肾轴的概念正受到越来越多的关注，这是由于肠道微生物群与肾脏疾病之间存在密切关系。腹膜透析被认为是终末期肾病（ESRD）的一种重要肾脏替代疗法。然而，对于接受这种透析方法后肠道微生物群的变化及其相关机制，目前还不完全清楚。本研究对 11 名未接受透析的终末期肾病患者（ESRD_N）和 7 名接受腹膜透析的患者（ESRD_P）的粪便样本进行了鸟枪法宏基因组测序。在对数据进行质量控制和相关性分析后，我们旨在探讨腹膜透析对 ESRD 患者肠道微生物群和健康的影响。我们的研究结果表明，ESRD_P 患者肠道微生物群相互作用的复杂性和聚集特征增加。此外，肠道微生物群驱动 ESRD_P 患者中倍半萜和三萜的生物合成途径，这可能有助于血液净化和改善循环。因此，我们的研究将为 ESRD 的预防和治疗奠定基础。
