School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Cell Infect Microbiol. 2022 Apr 25;12:873304. doi: 10.3389/fcimb.2022.873304. eCollection 2022.
Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Non-coding RNAs (ncRNAs), are RNAs that do not code for proteins, play a key role in biological processes and disease development associated with EV71. In this review, we summarized recent advances concerning the impacts of ncRNAs on neurological diseases caused by interaction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, diagnosis and treatment of EV71-induced neurological complications.
肠道病毒 71 型（EV71）是引起手足口病（HFMD）的主要致病病毒。研究报道，EV71 诱导的感染包括无菌性脑膜炎、急性弛缓性麻痹，甚至神经源性肺水肿，可导致婴儿、幼儿和免疫抑制人群发生严重的神经并发症。然而，EV71 引起神经系统疾病的机制尚未完全阐明。非编码 RNA（ncRNA）是指不编码蛋白质的 RNA，在与 EV71 相关的生物学过程和疾病发展中发挥着关键作用。在这篇综述中，我们总结了 ncRNA 对 EV71 与宿主相互作用引起的神经系统疾病影响的最新进展，揭示了 ncRNA 在 EV71 诱导的神经并发症发病机制、诊断和治疗中的潜在作用。
