Maino Vieytes Christian A, Rodriguez-Zas Sandra L, Madak-Erdogan Zeynep, Smith Rebecca L, Zarins Katie R, Wolf Gregory T, Rozek Laura S, Mondul Alison M, Arthur Anna E
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Front Nutr. 2022 Apr 25;9:791141. doi: 10.3389/fnut.2022.791141. eCollection 2022.
No studies, to date, have scrutinized the role of dietary patterns on prognosis following a head and neck squamous cell carcinoma (HNSCC) diagnosis. The purpose of this analysis was to evaluate the associations between adherence to six defined diet quality indices (including AHEI-2010, aMED, DASH, and three low-carbohydrate indices) throughout the first 3 years of observation and all-cause and cancer-specific mortalities in 468 newly diagnosed HNSCC patients from the University of Michigan Head and Neck Specialized Program of Research Excellence (UM-SPORE). The dietary intake data were measured using a food frequency questionnaire administered at three annual time points commencing at study entry. Deaths and their causes were documented throughout the study using various data sources. Marginal structural Cox proportional hazards models were used to evaluate the role of diet quality, as a time-varying covariate, on mortality. There were 93 deaths from all causes and 74 cancer-related deaths adjudicated throughout the observation period. There was a strong inverse association between adherence to the AHEI-2010, all-cause mortality (HR :0.07, 95% CI:0.01-0.43, :0.04), and cancer-specific mortality (HR :0.15, 95% CI:0.02-1.07, :0.04). Other more modest associations were noted for the low-carbohydrate indices. In sum, higher adherence to the AHEI-2010 and a plant-based low-carbohydrate index throughout the first 3 years since diagnosis may bolster survival and prognosis in newly diagnosed patients with HNSCC.
迄今为止，尚无研究仔细审查饮食模式对头颈部鳞状细胞癌（HNSCC）诊断后预后的作用。本分析的目的是评估在密歇根大学头颈卓越研究专项计划（UM-SPORE）中468例新诊断的HNSCC患者的观察期前3年内，遵循六种定义的饮食质量指数（包括AHEI-2010、aMED、DASH和三种低碳水化合物指数）与全因死亡率和癌症特异性死亡率之间的关联。饮食摄入数据通过在研究开始时的三个年度时间点进行的食物频率问卷调查来测量。在整个研究过程中，使用各种数据源记录死亡情况及其原因。采用边际结构Cox比例风险模型评估饮食质量作为随时间变化的协变量对死亡率的作用。在整个观察期内，共有93例全因死亡和74例癌症相关死亡经判定。遵循AHEI-2010与全因死亡率（HR：0.07，95%CI：0.01-0.43，P：0.04）和癌症特异性死亡率（HR：0.15，95%CI：0.02-1.07，P：0.04）之间存在强烈的负相关。低碳水化合物指数也存在其他较适度的关联。总之，在诊断后的前3年中，更高程度地遵循AHEI-2010和基于植物的低碳水化合物指数可能会提高新诊断的HNSCC患者的生存率和预后。
