Du Yanlong, Yu Aimin, Jia Jiru, Zhang Youquan, Meng Xiangtai
Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering Tianjin University of Technology, Tianjin 300384, P. R. China.
Chem Commun (Camb). 2017 Jan 31;53(10):1684-1687. doi: 10.1039/c6cc08996h.
A protocol for the direct functionalization of N-H/α,α,β,β-C(sp)-H of piperidine without any metal or external oxidants is reported. This reaction is promoted by 4-(trifluoromethyl)benzoic acid via an azomethine ylide intermediate. This is a simple method for the synthesis of spirooxindoles bearing 3-substituted oxindole moieties.
报道了一种无需任何金属或外部氧化剂即可直接将哌啶的N-H/α,α,β,β-C(sp)-H官能化的方案。该反应由4-(三氟甲基)苯甲酸通过甲亚胺叶立德中间体促进。这是一种合成带有3-取代吲哚酮部分的螺吲哚酮的简单方法。
