He Zhikuan, Dong Wenxing, Yao Kunhou, Qin Changjiang, Duan Baomin
Department of General Surgery, Henan University Huaihe Hospital Kaifeng 475000 Henan Province China.
Department of Emergency, Kaifeng Central Hospital 58 East Street Kaifeng 475000 Henan Province China
RSC Adv. 2018 Oct 8;8(60):34483-34490. doi: 10.1039/c8ra05583a. eCollection 2018 Oct 4.
Daphnetin (7,8-dihydroxycoumarin), a natural coumarin compound, has shown antitumor and energy metabolism regulatory activities. However, the effects of daphnetin on cell proliferation, migration, and glucose metabolism in colorectal cancer (CRC) cells remains unknown. In this study, the effects of daphnetin on CRC cell proliferation, migration, and glucose metabolism have been examined. The results showed that daphnetin inhibited the proliferation, migration, and invasion of CRC cells, and induced CRC cell apoptosis. Furthermore, daphnetin suppressed intracellular glucose and lactate production, and downregulated the expression of hexokinase 2 (HK2) and glucose transporter 1 (GLUT1) in CRC cells. Furthermore, daphnetin prevented activation of the PI3K/Akt pathway in CRC cells. These findings demonstrated that daphnetin inhibited the proliferation, migration and glucose metabolism in CRC cells by suppressing the PI3K/Akt signaling pathway. Therefore, daphnetin has potential as a novel anticancer agent for CRC treatment.
瑞香素（7,8 - 二羟基香豆素）是一种天然香豆素化合物，已显示出抗肿瘤和能量代谢调节活性。然而，瑞香素对结直肠癌（CRC）细胞增殖、迁移和葡萄糖代谢的影响仍不清楚。在本研究中，已检测了瑞香素对CRC细胞增殖、迁移和葡萄糖代谢的影响。结果表明，瑞香素抑制CRC细胞的增殖、迁移和侵袭，并诱导CRC细胞凋亡。此外，瑞香素抑制细胞内葡萄糖和乳酸生成，并下调CRC细胞中己糖激酶2（HK2）和葡萄糖转运蛋白1（GLUT1）的表达。此外，瑞香素可阻止CRC细胞中PI3K/Akt途径的激活。这些发现表明，瑞香素通过抑制PI3K/Akt信号通路来抑制CRC细胞的增殖、迁移和葡萄糖代谢。因此，瑞香素具有作为新型抗癌剂用于CRC治疗的潜力。
