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一种新型吡唑并[1,5 - ]吡啶荧光团及其在细胞内检测pH值的应用。

A novel pyrazolo[1,5-]pyridine fluorophore and its application to detect pH in cells.

作者信息

Zhang Ping, Lv Huaying, Duan Guiyun, Dong Jian, Ge Yanqing

机构信息

School of Chemistry and Pharmaceutical Engineering, Taishan Medical University Taian Shandong 271016 P. R. China

Laigang Hospital Affiliated to Taishan Medical University Lai'wu 271126 P. R. China.

出版信息

RSC Adv. 2018 Aug 31;8(54):30732-30735. doi: 10.1039/c8ra06191b. eCollection 2018 Aug 30.

DOI:10.1039/c8ra06191b
PMID:35548712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9085528/
Abstract

A new fluorescent probe based on pyrazolo[1,5-]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield ( = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change.

摘要

合成了一种基于吡唑并[1,5 - ]吡啶的新型荧光探针，并用于监测细胞内的pH值。该探针对酸性pH（小于10秒）表现出快速响应、高量子产率（ = 0.64）以及高选择性和灵敏度。荧光探针的响应机制依赖于ICT变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/03087f653dc8/c8ra06191b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/3b11f7a08cf5/c8ra06191b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/e5f13c4cf450/c8ra06191b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/49be8a9a5b97/c8ra06191b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/1fd2104ea5b1/c8ra06191b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/ecc00ba58432/c8ra06191b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/e8a875562c84/c8ra06191b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/03087f653dc8/c8ra06191b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/3b11f7a08cf5/c8ra06191b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/e5f13c4cf450/c8ra06191b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/49be8a9a5b97/c8ra06191b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/1fd2104ea5b1/c8ra06191b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/ecc00ba58432/c8ra06191b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/e8a875562c84/c8ra06191b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ea/9085528/03087f653dc8/c8ra06191b-s2.jpg

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