Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Department of Otorhinolaryngology, College of Medicine, Pusan National University, Busan, Republic of Korea.
Laryngoscope. 2023 Feb;133(2):383-388. doi: 10.1002/lary.30181. Epub 2022 May 12.
This study aimed to determine the optimal protocol of hyperbaric oxygen therapy (HBOT) according to various treatment settings for sudden sensorineural hearing loss (SSNHL).
A 112 patients with SSNHL were enrolled in this prospective study. All patients were treated with systemic steroid therapy, intratympanic steroid therapy, and HBOT. According to the pressure and duration of HBOT (10 sessions in total), the patients were divided into three groups: group 1, 2.5 atmospheres absolute (ATA) for 1 h; group 2, 2.5 ATA for 2 h; and group 3, 1.5 ATA for 1 h. The pure-tone average (PTA), word discrimination score (WDS), and mean gain were compared.
A total of 105 patients completed the 3-month follow-up, and 6 patients were excluded. Differences among groups were found in PTA, WDS, and mean gain. In the post-hoc analysis, group 3 had significantly lower WDS and mean gain than groups 1 and 2; however, group 2 showed no significant differences from group 1. The proportion of patients with hearing recovery after treatment was significantly higher in group 1 (57.6%) and group 2 (58.8%) than in group 3 (31.3%).
When HBOT (10 sessions) was combined with corticosteroids as the initial therapy for SSNHL, a higher pressure (1.5 ATA vs. 2.5 ATA) provided better treatment results; however, increasing the duration (1 h vs. 2 h) under 2.5 ATA did not result in a significant difference. Therefore, HBOT for SSNHL may be performed at 2.5 ATA for 1 h in 10 sessions. Laryngoscope, 133:383-388, 2023.
本研究旨在根据突发性聋（SSNHL）的不同治疗方案，确定高压氧治疗（HBOT）的最佳方案。
本前瞻性研究共纳入 112 例 SSNHL 患者。所有患者均接受全身皮质类固醇治疗、鼓室内皮质类固醇治疗和 HBOT。根据 HBOT 的压力和持续时间（共 10 次），患者被分为三组：1 组，2.5 绝对大气压（ATA）1 小时；2 组，2.5 ATA 2 小时；3 组，1.5 ATA 1 小时。比较纯音平均听阈（PTA）、言语辨别得分（WDS）和平均增益。
共有 105 例患者完成了 3 个月的随访，有 6 例患者被排除。在 PTA、WDS 和平均增益方面，三组之间存在差异。在事后分析中，3 组的 WDS 和平均增益明显低于 1 组和 2 组；然而，2 组与 1 组无显著差异。1 组（57.6%）和 2 组（58.8%）患者的治疗后听力恢复比例明显高于 3 组（31.3%）。
当 HBOT（10 次）与皮质类固醇联合作为 SSNHL 的初始治疗时，较高的压力（1.5 ATA 与 2.5 ATA）可获得更好的治疗效果；然而，在 2.5 ATA 下增加持续时间（1 小时与 2 小时）并未产生显著差异。因此，SSNHL 的 HBOT 可能在 10 次 2.5 ATA 治疗中每次 1 小时。《喉镜》，133：383-388，2023。
