, a key regulator of ageing and age-related neurodegenerative diseases.

are Nicotinamide Adenine Dinucleotide (NAD) dependent class ІΙΙ histone deacetylases enzymes (HDACs) present from lower to higher organisms such as bacteria ( L. major), yeasts (), nematodes (), fruit flies (), humans (), even in plants such as rice (), thale cress (), vine ( L.) tomato (). play an important role in the regulation of various vital cellular functions during metabolism and ageing. It also plays a neuroprotective role by modulating several biological pathways such as apoptosis, DNA repair, protein aggregation, and inflammatory processes associated with ageing and neurodegenerative diseases. In this review, we have presented an updated and its role in ageing and age-related neurodegenerative diseases (NDDs). Further, this review also describes the therapeutic potential of and the use of inhibitor/activator for altering the NDDs disease pathology.