Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, United States of America.
Institute for Drug Delivery and Biomedical Research, Bengaluru 560086, India.
Eur J Pharm Sci. 2022 Aug 1;175:106203. doi: 10.1016/j.ejps.2022.106203. Epub 2022 May 10.
The Polymer Coated Polymeric (PCP) microneedles were fabricated using PVP K30 in the core and ethyl cellulose in the coating. The PCP microneedles do not disintegrate in the tissue upon insertion and rather stays intact and allows diffusion of drugs and analytes across the membrane both inward and outward. In this project the potential use of PCP microneedles for sampling analytes from the dermal tissue was explored. The amount of analyte sampled depended on the concentration in the tissue, physicochemical properties of the analyte and duration of insertion of the array in the tissue. Further, an advanced type of PCP microneedle array was fabricated by entrapping absorbent beads in the core microneedles. The adsorbent enabled the PCP microneedles to recover significantly higher amount of analyte from the tissue.
聚合物涂层聚合物（PCP）微针采用 PVP K30 作为芯材，乙基纤维素作为涂层材料制成。PCP 微针在插入组织时不会分解，而是保持完整，并允许药物和分析物在膜内外扩散。在这个项目中，探索了 PCP 微针用于从皮肤组织中采样分析物的潜在用途。采样的分析物数量取决于组织中的浓度、分析物的物理化学性质以及微针阵列在组织中插入的时间。此外，通过将吸收剂珠粒包埋在芯微针中，制造了一种先进的 PCP 微针阵列。这种吸附剂使 PCP 微针能够从组织中回收更多的分析物。
