Kulkarni Deepak, Damiri Fouad, Rojekar Satish, Zehravi Mehrukh, Ramproshad Sarker, Dhoke Dipali, Musale Shubham, Mulani Ashiya A, Modak Pranav, Paradhi Roshani, Vitore Jyotsna, Rahman Md Habibur, Berrada Mohammed, Giram Prabhanjan S, Cavalu Simona
Department of Pharmaceutics, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.
Laboratory of Biomolecules and Organic Synthesis (BIOSYNTHO), Department of Chemistry, Faculty of Sciences Ben M'Sick, University Hassan II of Casablanca, Casablanca 20000, Morocco.
Pharmaceutics. 2022 May 20;14(5):1097. doi: 10.3390/pharmaceutics14051097.
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology due to its multifaceted and broad-spectrum applications. This review broadly discusses MN's types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.
微针（MNs）技术是全球生物医学科学领域的一项最新进展。基于微针的药物递送可以克服当前药物递送的局限性，如吸收差、生物利用度低、皮肤渗透不足和生物分布不佳等问题。纳米技术极大地改变了微针（MNs）的制造技术，其设计从传统转向新颖，采用了各种天然和合成材料及其组合。如今，由于其多方面和广谱的应用，微针技术在生物医学研究和药物递送技术领域已在全球范围内受到欢迎。本综述广泛讨论了微针的类型、制造方法、组成、表征、应用、最新进展以及全球知识产权情况。
