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CCL19 有望成为乳腺癌的潜在预后生物标志物和肿瘤免疫微环境（TIME）调节剂：基于 TCGA 数据库的综合分析。

CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database.

机构信息

Department of Oncology, Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

Department of Pathology, Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

出版信息

Aging (Albany NY). 2022 May 12;14(9):4158-4175. doi: 10.18632/aging.204081.

DOI:10.18632/aging.204081
PMID:35550569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9134962/
Abstract

The development of cancer was determined by not only the intrinsic properties of cancer cells, but also the communication between cancer cells and tumor microenvironment (TME). We applied ESTIMATE and CIBERSORT algorithms to calculate the immune/stromal component and tumor-infiltrating immune cells (TICs) in TME of BC. The results showed that immune component in TME predicted patients' survival and associated with progression of BC. Differentially expressed genes (DEGs) were primarily enriched in immune-related activities. Finally, CCL19 was acquired which shared the leading nodes in PPI network and was associated with patients' survival. High expression of CCL19 predicted better prognosis and participated in progression of BC. Genes in CCL19 up-regulated group were enriched in immune-related activities and these functions might depend on the communications between CCL19 and multiple TICs in TIME. In conclusion, CCL19 functioned as a potential prognostic biomarker and a modulator of TIME in BC through communicating with various TICs.

摘要

癌症的发展不仅取决于癌细胞的内在特性，还取决于癌细胞与肿瘤微环境（TME）之间的通讯。我们应用 ESTIMATE 和 CIBERSORT 算法来计算 BC 中 TME 的免疫/基质成分和肿瘤浸润免疫细胞（TIC）。结果表明，TME 中的免疫成分预测了患者的生存，并与 BC 的进展相关。差异表达基因（DEGs）主要富集在免疫相关的活性中。最后，获得了 CCL19，其在 PPI 网络中与共享主导节点，并与患者的生存相关。CCL19 的高表达预示着更好的预后，并参与了 BC 的进展。CCL19 上调组中的基因富集在免疫相关的活性中，这些功能可能依赖于 CCL19 与 TME 中多种 TIC 之间的通讯。总之，CCL19 通过与各种 TIC 通讯，在 BC 中作为潜在的预后生物标志物和 TME 的调节剂发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/38acb4f57383/aging-14-204081-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/9d3595a4d01a/aging-14-204081-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/1f3a7df7cc4a/aging-14-204081-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/1980e996d9c0/aging-14-204081-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/01df48db4f9a/aging-14-204081-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/38acb4f57383/aging-14-204081-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/9d3595a4d01a/aging-14-204081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/ce4567de45e9/aging-14-204081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/548f78eeeba8/aging-14-204081-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/1f3a7df7cc4a/aging-14-204081-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/1980e996d9c0/aging-14-204081-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/01df48db4f9a/aging-14-204081-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/9134962/38acb4f57383/aging-14-204081-g007.jpg

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