Andriole V T
Am J Med. 1987 Apr 27;82(4A):67-70.
The antibacterial efficacy of some of the newer quinolone antimicrobial agents in general, and ciprofloxacin in particular, in animal models of experimental septic arthritis, burn wound sepsis, empyema, chronic gastroenteritis, granuloma pouch infection, intraabdominal abscess, osteomyelitis, prostatis, sinusitis, urinary tract infection, and severe septicemia caused by Pseudomonas aeruginosa is reviewed. In addition, the efficacy of these newer quinolones has been studied in animal models of pneumonia, endocarditis, meningitis, skin and soft tissue infections, and a variety of other systemic infections. Although certain limitations are associated with animal models of infection, properly performed studies clearly have the potential to provide guidelines for evaluating the efficacy of antimicrobial agents in the treatment of some infections in humans.
综述了一些新型喹诺酮类抗菌药物，特别是环丙沙星，在实验性脓毒性关节炎、烧伤创面脓毒症、脓胸、慢性胃肠炎、肉芽肿袋感染、腹腔脓肿、骨髓炎、前列腺炎、鼻窦炎、尿路感染以及由铜绿假单胞菌引起的严重败血症等动物模型中的抗菌效果。此外，还在肺炎、心内膜炎、脑膜炎、皮肤和软组织感染以及多种其他全身感染的动物模型中研究了这些新型喹诺酮类药物的疗效。尽管感染动物模型存在一定局限性，但正确开展的研究显然有可能为评估抗菌药物治疗人类某些感染的疗效提供指导。
