Turkish Ministry of Health Ankara City Hospital, Bilkent, Ankara, Turkey.
Department of Biostatistics, Cukurova University, Adana, Turkey.
Nutrition. 2022 Jul-Aug;99-100:111683. doi: 10.1016/j.nut.2022.111683. Epub 2022 Apr 11.
The aim of this study was to assess the association of vitamin D levels with vitamin B and folate levels in children.
A cross-sectional retrospective study was conducted with 7181 children whose vitamin D, vitamin B, and folate levels were measured simultaneously and analyzed. The mean age of the patients was 10.1 ± 5.2 y (median 10 y). Of the 7181 children in the study, 4047 (56.4%) were girls and 3134 (43.6%) were boys. The children were placed into one of four groups depending on their vitamin D level. Group 1's vitamin D level was <10 ng/mL (n = 2408; 33.5%), group 2: 10 to 19 ng/mL (n = 2504; 34.9%), group 3: 20 to 29 ng/mL (n = 1570; 21.9%), and group 4: ≥30 ng/mL (n = 699; 9.7%). The correlations of vitamin D levels with B and folate were analyzed by Spearman's correlation test.
We detected positive, weak but significant correlation between vitamin D and vitamin B12/folate (r = 0.240, P < 0.001 and r = 0.245, P = 0.001, respectively).
The present study reported a positive correlation between vitamin D and vitamin B and folate levels. Regular measurement of these two micronutrient levels in children with vitamin D deficiency is important for public health.
本研究旨在评估儿童维生素 D 水平与维生素 B 和叶酸水平之间的关联。
对同时检测并分析了 7181 名儿童的维生素 D、维生素 B 和叶酸水平的横断面回顾性研究。患者的平均年龄为 10.1 ± 5.2 岁（中位数为 10 岁）。在这项研究的 7181 名儿童中，4047 名（56.4%）为女孩，3134 名（43.6%）为男孩。根据维生素 D 水平，将儿童分为四组。第 1 组的维生素 D 水平<10ng/mL（n=2408；33.5%），第 2 组：10-19ng/mL（n=2504；34.9%），第 3 组：20-29ng/mL（n=1570；21.9%），第 4 组：≥30ng/mL（n=699；9.7%）。采用 Spearman 相关检验分析维生素 D 水平与 B 和叶酸的相关性。
我们发现维生素 D 与维生素 B12/叶酸之间存在正相关，相关性较弱但有统计学意义（r=0.240，P<0.001 和 r=0.245，P=0.001）。
本研究报道了维生素 D 与维生素 B 和叶酸水平之间存在正相关。定期检测维生素 D 缺乏儿童这两种微量营养素的水平，对公共卫生具有重要意义。
